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Rp-TTP-α-S

Thymidine- 5'- O- (1-thiotriphosphate), Rp-isomer ( Rp-TTP-α-S ), sodium salt
Cat. No.: T 002
    
CAS No.: [83199-35-3]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: T 002-05
Unit: 5 µmol / ~2.5 mg
$303.00

For other salt forms or a guaranteed higher purity please inquire. Useful for modulation of TTP-responsive receptors and determination of their stereospecificity. Increased metabolic stability compared to TTP. Not accepted by DNA polymerases. Detailed technical information available. Reference: Abbotts et al., J. Biol. Chem., 263, 15094 - 15103 (1988).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. T 002
CAS number [83199-35-3]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₀H₁₇N₂O₁₃P₃S (free acid)
Molecular weight [g/mol] 498.2 (free acid)
Absorption max [nm] 267
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 9600
  • 1. Ryder S. P.Strobel S. A., Methods Enzymol., 18, 38 - 50 (1999), "Nucleotide Analog Interference Mapping"
  • 2. Eckstein F.Thomson J. B., Methods Enzymol., 262, 189 - 202 (1995), "Phosphate Analogs for Study of DNA Polymerases"
  • 3. Arabshani A.Frey P. A., Biochem. Biophys. Res. Commun., 204, 150 - 155 (1994), "A Simplified Procedure for Synthesizing Nucleoside 1-Thiotriphosphates: dATP-alpha-S, dGTP-alpha-S, UTP-alpha-S and dTTP-alpha-S"
  • 4. Abbotts J., SenGupta D. N., Zon G.Wilson S. H., J. Biol. Chem., 263, 15094 - 15103 (1988), "Studies on the Mechanism of Escherichia coli DNA Polymerase I Large Fragment"
  • 5. Goody R. S.Isakov M., Tetrahedron Lett., 27, 3599 - 3602 (1986), "Simple Synthesis and Separation of the Diastereomers of alpha-Thio Analogs of Ribo- and Deoxyribo-di- and Triphosphates"