For other salt forms or a guaranteed higher purity please inquire.
Modulator of GTP binding proteins with often increased metabolic stability. Useful for characterization of GTP-responsive receptors and determination of their stereospecificity. Detailed technical information available. References: Koch et al., J. Biol. Chem., 265, 9659 - 9663 (1990); Von zur Muehlen et al., Int. Arch. Allergy Appli. Immunol., 94, 74 - 75 (1991).
Vial containing 500 µl of 10 mM aqueous solution of pH 7.6
| Cat. No. | G 014 |
| CAS number | [81570-50-5] |
| Purity | > 95% HPLC |
| Salt form | Sodium |
| Appearance | 10 mM aqueous solution of pH 7.6 |
| Storage temperature | -70°C / -94°F |
| Molecular formula | C₁₀H₁₆N₅O₁₃P₃S (free acid) |
| Molecular weight [g/mol] | 539.3 (free acid) |
| Absorption max [nm] | 252 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 14300 |
- 1. Ryder S. P.Strobel S. A., Methods Enzymol., 18, 38 - 50 (1999), "Nucleotide Analog Interference Mapping"
- 2. Xu S. H.Gaskin F., Biochim. Biophys. Acta, 1383, 111 - 122 (1998), "Probing the ATP Binding Site of Tubulin with Thiotriphosphate Analogues of ATP"
- 3. Schaertl S., Konrad M.Geeves M. A., J. Biol. Chem., 273, 5662 - 5669 (1998), "Substrate Specificity of Human Nucleoside-diphosphate Kinase Revealed by Transient Kinetic Analysis"
- 4. Koch K. W., Eckstein F.Stryer L., J. Biol. Chem., 265, 9659 - 9663 (1996), "Stereochemical Course of the Reaction Catalyzed by Guanylate Cyclase from Bovine Retinal Rod Outer Segments"
- 5. Von zur Muehlen F.Penner R., Int. Arch. Allergy Appl. Immunol., 94, 74 - 75 (1991), "A GTP Analog Induces Calcium Release But Not Secretion in Rat Mast Cells"
- 6. Tucker J., Sczakiel G., Feuerstein J., John J., Goody R. S.Wittinghofer A., EMBO J., 5, 1351 - 1358 (1986), "Expression of p21 Proteins in Escherichia coli and Stereochemistry of the Nucleotide-binding Site"
- 7. Goody R. S.Isakov M., Tetrahedron Lett., 27, 3599 - 3602 (1986), "Simple Synthesis and Separation of the Diastereomers of alpha-Thio Analogs of Ribo- and Deoxyribo-di- and Triphosphates"
- 8. Lee M. H., Goody R. S.Nowak T., Biochemistry, 24, 7594 - 7602 (1985), "Guanosine Thiophosphate Derivatives as Substrate Analogues for Phosphoenolpyruvate Carboxykinase"
- 9. Yamanaka G., Eckstein F.Stryer L., Biochemistry, 24, 8094 - 8101 (1985), "Stereochemistry of the Guanyl Nucleotide Binding Site of Transducin Probed by Phosphorothioate Analogues of GTP and GDP"
- 10. Tomasselli A. G., Marquetant R., Noda L. H.Goody R. S., Eur. J. Biochem., 142, 287 - 289 (1984), "The Use of Phosphorothioate Diastereomers to Define the Structure of Metal-nucleotide Bound to GTP-AMP and ATP-AMP Phosphotransferase from Beef-heart Mitochondria"
- 11. Marquetant R.Goody R. S., J. Chromatogr., 280, 386 - 389 (1983), "An Improved Separation of Diastereomers of Nucleoside Phosphorothioates Using Reversed-phase High-Performance Liquid Chromatography"
- 12. Rösch P., Kalbitzer H. R.Goody R. S., FEBS Lett., 121, 211 - 214 (1980), "31P-NMR Spectra of Thiophosphate Analogues of Guanosine Nucleotides"
