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Alternative structural projections:

Rp-8-PIP-cAMPS

8- Piperidinoadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-PIP-cAMPS ), sodium salt
Lipophilic, site-selective analogue of the protein kinase A inhibitor Rp-cAMPS
Cat. No.: P 004
    
CAS No.: [156816-36-3]
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Product Name Price (net) Qty
Cat. No.: P 004-05
Unit: 5 µmol / ~2.3 mg
$353.00
For other salt forms please inquire. Lipophilic site-selective analogue of the protein kinase A inhibitor Rp-cAMPS (Cat. No. A 002) with extremely high preference for site B of cAK type II. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane-permeant compared to Rp-cAMPS. Detailed technical information and updated reference list available on request. Reference: Øgreid et al., Eur. J. Biochem., 221, 1089 - 1094 (1994).
Cat. No. P 004
CAS number [156816-36-3]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₅H₂₀N₆O₅PS · Na
Molecular weight [g/mol] 450.4
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Modifications 8-cAMP
Target PKA (cAK) Inhibitor
Lipophilicity 2.26
Absorption max [nm] 273
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15000
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  • 2. Johansson C., Aandahl E. M., Aukrust P., Müller F., Hansson V., Froeland S. S.Tasken K., 12th Protein Kinase Symp. NO/cGMP and Protein Kinase Signaling Bad Brückenau/Germany, 0, 0 - 0 (2000), "Protein Kinase A Type I Antagonist as an Immune-Modulating Therapy"
  • 3. Hemmings H. C., in Regulatory Protein Modification: Techniques and Protocols H.C. Hemmings (ed.) Humana Press Inc., 0, 121 - 218 (1996), "Protein Kinase and Phosphatase Inhibitors. Applications in Neuroscience"
  • 4. Yu S.-M., Cheng Z.-J.Kuo S.-C., Br. J. Pharmacol., 114, 1227 - 1235 (1995), "Antiproliferative Effects of A02011-1, an Adenylate Cyclase Activator, in Cultured Vascular Smooth Muscle Cells of Rat"
  • 5. Oegreid D., Dostmann W., Genieser H.-G., Niemann P., Doeskeland S. O.Jastorff B., Eur. J. Biochem., 221, 1089 - 1094 (1994), "(Rp)- and (Sp)- 8- Piperidinoadenosine- 3', 5'- (cyclic) Thiophosphates Discriminate Completely Between Site A and B of the Regulatory Subunits of cAMP-dependent Protein Kinase Type I and II"
  • 6. Bologa C., Muresan S., Liauw S., Iwitzki F.Chiriac A., Anal. Univ. Timisoara, 2, 27 - 36 (1993), "Quantitative Structure-Activity Study by the MTD-Method for cAMP-Derivatives with Large Substituents in Positions 2 and 8"