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Alternative structural projections:


8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-CPT-cAMPS ), sodium salt
Membrane-permeant and PDE-resistant PKA inhibitor
Cat. No.: C 011
CAS No.: [129735-01-9]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 011-05
Unit: 5 µmol / ~2.5 mg
highly purified, fluorescent impurities removed. For other salt forms please inquire. Lipophilic analog of Rp-cAMPS (Cat. No. A 002). Potent competitive inhibitor of protein kinase A type I and II (cyclic AMP antagonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Considerably more lipophilic and membrane-permeant compared to Rp-8-Br-cAMPS (Cat. No. B 001). Detailed technical information and updated reference list available on request. Reference: Weisskopf et al., Science, 265, 1878 - 1882 (1994).
Cat. No. C 011
CAS number [129735-01-9]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₆H₁₄ClN₅O₅PS₂ · Na
Molecular weight [g/mol] 509.8
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Modifications 8-cAMP
Target PKA (cAK) Inhibitor
Lipophilicity 2.72
Absorption max [nm] 282
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000
  • 1. Zieba B. J., Artamonov M. V., Jin L., Momotani K., Ho R., Franke A. S., Neppl R. L., Stevenson A. S., Khromov A. S., Chrzanowska-Wodnicka M.Somlyo A. V., J. Biol.Chem., 286, 16681 - 16692 (2011), "The cAMP-Responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity"
  • 2. Roscioni S. S., Maarsingh H., Elzinga C. R. S., Schuur J., Menzen M., Halayko A. J., Meurs H.Schmidt M., J. Cell. Mol. Med., 15, 1551 - 1563 (2011), "Epac as a Novel Effector of Airway Smooth Muscle Relaxation"
  • 3. Holz G. G., Chepurny O. G., Leech C. A., Dzhura I., Kelley G. G., Roe W. R., Dzhura E., Li X., Schwede F.Genieser H.-G., Biophys. J., 98, 680 - 680 (2010), "A Permissive Role for Protein Kinase A in Support of Epac Agonist-Stimulated Human Islet Insulin Secretion"
  • 4. Idevall-Hagren O., Barg S., Gylfe E.Tengholm A., J. Biol. Chem., 285, 23007 - 23018 (2010), "cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single Beta-cells"
  • 5. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
  • 6. Waldkirch E. S., Ückert S., Sigl K., Satzger I., Geismar U., Langnäse K., Richter K., Sohn M., Kuczyk M. A.Hedlund P., J. Sex. Med., 7, 2104 - 2111 (2010), "Expression of Cyclic AMP-Dependent Protein Kinase Isofor Human Cavernous Arteries: Functional Significance and Rela Phosphodiesterase Type 4"
  • 7. Grandoch M., de Jesus B. M., Oude Weernink P. A., Weber A. A., Jakobs K. H.Schmidt M., Cell Signal, 4, 609 - 621 (2009), "B Cell Receptor-induced Growth Arrest and Apoptosis in WEHI-231 Immature B Lymphoma Cells Involve Cyclic AMP and Epac Proteins"
  • 8. Waidmann O., Pleli T., Dvorak K., Baehr C., Mondorf U., Plotz G., Biondi R. M., Zeuzem S.Piiper A., J.Biol.Chem., 284, 32256 - 32263 (2009), "Inhibition of the Equilibrative Nucleoside Transporter 1 and Activation of A2A Adenosine Receptors by 8-(4-Chlorophenylthio)-modified cAMP Analogs and their Hydrolytic Products"
  • 9. Friis U. G., Stubbe J., Uhrenholt T. R., Svenningsen P., Nüsing R., Skott O.Jensen B. L., Amer. J. Physiol.-Renal Physiol. Zitat unvollständig, 289, 989 - 997 (2008), "Prostaglandin E2 EP2 and EP4 Receptor Activation Mediated cAMP-Dependent Hyperpolarization and Exocytosis of Renin in Juxtaglomerular Cells"
  • 10. Gonzalez-Iglesias A. E., Jiang Y., Tomic M., Kretschmannova K., Andric S. A., Zemkova H.Stojilkovic S. S., Mol. Endocrinol., 20, 2231 - 2246 (2006), "Dependence of Electrical Activity and Calcium Influx-controlled Prolactin Release on Adenylyl Cyclase Signaling Pathway in Pituitary Lactotrophs"
  • 11. De Jesus M. L., Stope M. B., Oude Weernink P. A., Mahlke Y., Börgermann C., Ananba V. N., Rimmbach C., Rosskopf D., Michel M. C., Jakobs K. H.Schmidt M., J. Biol. Chem. 21837 21847, 281, 21837 - 21847 (2006), "Cyclic-AMP-dependent and Epac-mediated Activation of R-Ras by G Protein-coupled Receptors Leads to Phospholipase D Stimulation"
  • 12. Son Y. K., Park W. S., Kim S. J., Earm Y. E., Kim N., Youm J. B., Warda M., Kim E.Han J., Biochem. Biophys. Res. Commun., 341, 931 - 937 (2006), "Direct Inhibition of a PKA Inhibitor, H-89 on K-V Channels in Rabbit Coronary Arterial Smooth Muscle Cells"
  • 13. Prieto D., Rivera L., Recio P., Rubio J. L. R., Hernandez M.Garcia-Sacristan A., J. Urol., 175, 1164 - 1170 (2006), "Role of Nitric Oxide in the Relaxation Elicited by Sildenafil in Penile Resistance Arteries"
  • 14. Park W. S., Son Y. K., Kim N., Youm J. B., Joo H., Warda M., Ko J. H., Earm Y. E.Han J., Biochem. Biophys. Res. Commun., 340, 1104 - 1110 (2006), "The Protein Kinase A Inhibitor, H-89, Directly Inhibits K-ATP and Kir Channels in Rabbit Coronary Arterial Smooth Muscle Cells"
  • 15. Müller D., Cortes-Dericks L., Budnik L. T., Brunswig-Spickenheier B., Pancratius M., Speth R. C., Mukhopadhyay A. K.Middendorff R., Endocrinology, 147, 2974 - 2985 (2006), "Homologous and Lysophosphatidic Acid-induced Desensitization of the Atrial Natriuretic Peptide Receptor, Guanylyl Cyclase-A, in MA-10 Leydig Cells"
  • 16. Lubomirov L. T., Reimann K., Metzler D., Hasse V., Stehle R., Ito M., Hartshorne D. J., Gagov H., Pfitzer G.Schubert R., Circ. Res., 98, 1159 - 1167 (2006), "Urocortin-induced Decrease in Ca2+ Sensitivity of Contraction in Mouse Tail Arteries is Attributable to cAMP-dependent Dephosphorylation of MYPT1 and Activation of Myosin Light Chain Phosphatase"
  • 17. Sung Y. J., Chiu D. T. W.Ambron R. T., Neuroscience, 141, 697 - 709 (2006), "Activation and Retrograde Transport of Protein Kinase G in Rat Nociceptive Neurons After Nerve Injury and Inflammation"
  • 18. Aronoff D. M., Carstens J. K., Chen G. H., Toews G. B.Peters-Golden M., J. Interferon Cytokine Res., 26, 827 - 833 (2006), "Differences Between Macrophages and Dentritic Cells in the Cyclic AMP-Dependent Regulation of Lipopolysaccaride-Induced Cytokine and Chemokine Synthesis"
  • 19. Hernández M., Barahona M. V., Recio P., Benedito S., Martínez A. C., Rivera L., Garciá-Sacristán A., Prieto D.Orensanz L. M., Br. J. Pharmacol., 149, 100 - 109 (2006), "Neuronal and Smooth Muscle Receptors Involved in the PACAP- and VIP-Induced Relaxations of the Pig Urinary Bladder Neck"
  • 20. Fricke K., Schulz A., John H., Forssmann W.-G.Maronde E., Endocrinology, 146, 2060 - 2068 (2005), "Isolation and Characterization of a Novel POMC-derived Peptide from Hemofiltrate of Chronic Renal Failure Patients"
  • 21. Ouyang X. S., Winbow V. M., Patel L. S., Burr G. S., Mitchell C. K.O'Brien J., Mol. Brain Res., 135, 1 - 11 (2005), "Protein Kinase A Mediates Regulation of Gap Junctions Containing Connexin35 Through a Complex Pathway"
  • 22. Li S., Doss J. C., Hardee E. J.Quock R. M., Brain Res., 1038, 113 - 117 (2005), "Involvement of cyclic GMP-dependent Protein Kinase in Nitrous Oxide-induced Anxiolytic-like Behavior in the Mouse Light/Dark Exploration Test"
  • 23. Seldon P. M., Meja K. K.Giembycs M. A., Pulmon. Pharmacol. Therapeut., 18, 277 - 284 (2005), "Rolipram, salbutamol and prostaglandin E2 suppress TNFa release from human monocytes by activating Type II cAMP-dependent protein kinase"
  • 24. Cullen K., McCool J., Anwer M. S.Webster C. R., Am. J. Physiol. Gastrointest. Liver Physiol. G, 287, 334 - 343 (2004), "Activation of cAMP-Guanine Exchange Factor (cAMP-GEF) Confers Protein Kinase A Independent Protection from Hepatocyte Apoptosis"
  • 25. Yang H.-W., Hu X.-D., Zhang H.-M., Xin W.-J., Li M.-T., Zhang T., Zhou L.-J.Liu X.-G., J. Neurophysiol., 913, 1122 - 1133 (2004), "Roles of CaMKII, PKA, and PKC in the Induction and Maintainance of LTP of C-fiber-evoked Field Potentials in Rat Spinal Dorsal Horn"
  • 26. Rondaij M. G., Sellink E., Gijzen K. A., Ten Klooster J. P., Hordijk P. L., Van Mourik J. A.Voorberg J., Arterioscler. Thromb. Vasc. Biol., 24, 1315 - 1320 (2004), "Small GTP-Binding Protein Ral is Involved in cAMP-mediated Release of von Willebrand Factor From Endothelial Cells"
  • 27. Novara M., Baldelli P., Cavallari D., Carabelli V., Giancippoli A.Carbone E., J. Physiol., 558, 433 - 449 (2004), "Exposure to cAMP and (beta)-adrenergic Stimulation Recruits CaV3 T-type Channels in Rat Chromaffin Cells Through Epac cAMP-receptor Proteins"
  • 28. Dyachok O.Gylfe E., J. Biol. Chem., 279, 45455 - 45461 (2004), "Ca2+-induced Ca2+ Release via Inositol 1,4,5-triphosphate Receptors is Amplified by Protein Kinase A and Triggers Exocytosis in Pancreatic Beta-cells"
  • 29. Browner N. C., Sellak H.Lincoln T. M., Am. J. Physiol.-Cell Physiol., 287, 88 - 96 (2004), "Downregulation of cGMP-dependent Protein Kinase Expression by Inflammatory Cytokines in Vascular Smooth-muscle Cells"
  • 30. Schröder F., Klein G., Frank T., Bastein M., Indris S., Karck M., Drexler H.Wollert K. C., J. Mol. Cell. Cardiol., 37, 735 - 745 (2004), "Src Family Tyrosine Kinases Inhibit Single L-type: Ca2+ Channel Activity in Human Atrial Myocytes"
  • 31. Fricke K., Heitland A.Maronde E., Endocrinology, 145, 4940 - 4947 (2004), "Cooperative Activation of Lipolysis by Protein Kinase A and Protein Kinase C Pathways in 3T3-L1 Adipocytes"
  • 32. Waleh N., Kajino H., Marrache A. M., Ginzinger D., Roman C., Seidner S. R., Moss T. J. M., Fouron J. C., Vazquez-Tello A., Chemtob S.Clyman R. I., Circulation, 110, 2326 - 2332 (2004), "Prostaglandin E-2 Mediated Relaxation of the Ductus Arteriosus - Effects of Gestational Age on G Protein-coupled Receptor Expression, Signaling, and Vasomotor Control"
  • 33. Christensen A. E., Selheim F., de Rooij J., Dremier S., Schwede F., Dao K. K., Martinez A., Maenhaut C., Bos J. L., Genieser H.-G.Doeskeland S. O., J. Biol. Chem., 278, 35394 - 35402 (2003), "cAMP Analog Mapping of Epac1 and cAMP-Kinase. Discriminating Analogs Demonstrate that Epac and cAMP-Kinase Act Synergistically to Promote PC-12 Cell Neurite Extension"
  • 34. Sauzeau V., Rolli-Derkinderen M., Marionneau C., Loirand G.Pacaud P., J. Biol. Chem., 278, 9472 - 9480 (2003), "RhoA Expression is Controlled by Nitric Oxide through cGMP-dependent Protein Kinase Activation"
  • 35. West G. A., Meno J. R., Nguyen T.-S. K., Ngai A. C., Simard J. M.Winn H. R., J. Cardiovasc. Pharmacol., 41, 444 - 451 (2003), "cGMP-dependent and not cAMP-dependent Kinase is Required for Adenosine-induced Dilation of Intracerebral Arterioles"
  • 36. Zhu W. Z., Wang S. Q., Chakir K., Yang D. M., Zhang T., Brown J. H., Devic E., Kobilka B. K., Cheng H. P.Xiao R. P., J. Clin. Invest., 111, 617 - 625 (2003), "Linkage of Beta(1)-adrenergic Stimulation to Apoptotic Heart Cell Death through Protein Kinase A-independent Activation of Ca2+/Calmodulin Kinase II"
  • 37. Christensen A. E., de Rooij J., Kopperud R. K., Nilsen O. K., Dao K. K., Schwede F., Bos J. L., Genieser H.-G.Doeskeland S. O., Abstract of the 13th Protein Kinase Symposium, 0, 5 - 5 (2002), "Comparison of the cAMP Binding Sites of EPAC-1 and cAMP-Kinase"
  • 38. Gao Y. S.Raj J. U., Eur. J. Pharmacol., 436, 227 - 233 (2002), "Effects of SQ 22536, an Adenylyl Cyclase Inhibitor, on Isoproterenol-induced Cylic AMP Elevation and Relaxation in Newborn Ovine Pulmonary Veins"
  • 39. Abi-Gerges N., Szabo G., Otero A. S., Fischmeister R.Méry P.-F., J. Physiol.-London, 540, 411 - 424 (2002), "NO Donors Potentiate the Beta-Adrenergic Stimulation of I-Ca, I-L and the Muscarinic Activation of I-K, I-ACh in Rat Cardiac Myocytes"
  • 40. Constantinescu A., Gordon A. S.Diamond I., J. Biol. Chem., 277, 18810 - 18816 (2002), "cAMP-dependent Protein Kinase Types I and II Differentially Regulate cAMP Response Element-mediated Gene Expression. Implications for Neuronal Responses to Ethanol"
  • 41. Jang E. K., Azzam J. E., Dickinson N. T., Davidson M. M. L.Haslam R. J., Brit. J. Haematol., 117, 664 - 675 (2002), "Roles for Both Cyclic GMP and Cyclic AMP in the Inhibition of Collagen-induced Platelet Aggregation by Nitroprusside"
  • 42. Hsu K. S., Huang C. C., Liang Y. C., Wu H. M., Chen Y. L., Lo S. W.Ho W. C., Hippocampus, 12, 787 - 802 (2002), "Alterations in the Balance of Protein Kinase and Phosphatase Activities and Age-related Impairments of Synaptic Transmission and Long-Term Potentiation"
  • 43. Hahnefeld C.Herberg F. W., Abstract of the 13th Protein Kinase Symposium p. 14, 0, 12 - 15 (2002), "cAMP-dependent Protein Kinase: cAMP Analog Screening Using Surface Plasmon Resonance and Fluorescent Methods"
  • 44. Spicuzza L., Belvisi M. G., Birrell M. A., Barnes P. J., Hele D. J.Giembycz M. A., Br. J. Pharmacol., 133, 1201 - 1212 (2001), "Evidence that the Anti-Spasmogenic Effect of the Beta-Adrenoceptor Agonist, Isoprenaline, on Guinea-Pig Trachealis is not Mediated by Cyclic AMP-dependent Protein Kinase"
  • 45. Petroff M. G. V., Egan J. M., Wang X. L.Sollott S. J., Circ. Res., 89, 445 - 452 (2001), "Glucagon-like Peptide-1 Increases cAMP but Fails to Augment Contraction in Adult Rat Cardiac Myocytes"
  • 46. Staples K. J., Bergmann M., Tomita K., Houslay M. D., McPhee I., Barnes P. J., Giembycz M. A.Newton R., J. Immunol., 167, 2074 - 2080 (2001), "Adenosine 3', 5'-cyclic Monophosphate (cAMP)-dependent Inhibition of IL-5 from Human T Lymphocytes is not Mediated by the cAMP-dependent Protein Kinase A(1)"
  • 47. Lubomirov L., Gagov H., Petkova-Kirova P., Duridanova D., Kalentchuk V. U.Schubert R., Br. J. Pharmacol., 134, 1564 - 1570 (2001), "Urocortin Relaxes Rat Tail Arteries by a PKA-mediated Reduction of the Sensitivity of the Contractile Apparatus for Calcium"
  • 48. D'Alcantara P., Ledent C., Swillens S.Schiffmann S. N., Neuroscience, 107, 455 - 464 (2001), "Inactivation of Adenosine A(2A) Receptor Impairs Long Term Potentiation in the Accumbens Nucleus without Altering Basal Synaptic Transmission"
  • 49. Han J., Kim N., Kim E., Ho W.-K.Earm Y. E., J. Biol. Chem., 276, 22140 - 22147 (2001), "Modulation of ATP-sensitive Potassium Channels by cGMP-dependent Protein Kinase in Rabbit Ventricular Myocytes"
  • 50. Johansson C., Aandahl E. M., Aukrust P., Müller F., Hansson V., Froeland S. S.Tasken K., 12th Protein Kinase Symp. NO/cGMP and Protein Kinase Signaling Bad Brückenau/Germany, 0, 0 - 0 (2000), "Protein Kinase A Type I Antagonist as an Immune-Modulating Therapy"
  • 51. Tian L. J.Shipston M. J., Endocrinology, 141, 2930 - 2937 (2000), "Characterization of Hyperpolarization-Activated Cation Currents in Mouse Anterior Pituitary, AtT20 D16 : 16 Corticotropes"
  • 52. Kaufmann J. E., Oksche A., Wollheim C. B., Günther G., Rosenthal W.Vischer U. M., J. Clin. Invest., 106, 107 - 116 (2000), "Vasopressin-Induced von Willebrand Factor Secretion from Endothelial Cells Involves V2 Receptors and cAMP"
  • 53. Herkert O., Kuhl H., Busse R.Schini-Kerth V. B., Br. J. Pharmacol., 130, 1911 - 1918 (2000), "The Progestin Levonorgestrel Induces Endothelium-Independent Relaxation of Rabbit Jugular Vein via Inhibition of Calcium Entry and Protein Kinase C: Role of Cyclic AMP"
  • 54. King S. A.Sorscher E. J., Biochemistry, 39, 9868 - 9875 (2000), "R-Domain Interactions with Distal Regions of CFTR Lead to Phosphorylation and Activation"
  • 55. Schwede F., Maronde E., Genieser H.-G.Jastorff B., Pharmacol. Ther., 87, 199 - 226 (2000), "Cyclic Nucleotide Analogs as Biochemical Tools and Prospective Drugs"
  • 56. Keularts I. M. L. W., van Gorp R. M. A., Feijge M. A. H., Vuist W. M. J.Heemskerk J. W. M., J. Biol. Chem., 275, 1763 - 1772 (2000), "Alpha(2A)-Adrenergic Receptor Stimulation Potentiates Calcium Release in Platelets by Modulating cAMP Levels"
  • 57. Conigrave A. D., Van der Weyden L., Holt L., Jiang L., Wilson P., Christopherson R. L.Morris M. B., Biochem. Pharmacol., 60, 1585 - 1591 (2000), "Extracellular ATP-Dependent Suppression of Proliferation and Induction of Differentiation of Human HL-60 Leukemia Cells by Distinct Mechanisms"
  • 58. Zhang W. Z., Turner D. J., Segura B. J., Cowles R.Mulholland M. W., J. Surg. Res., 94, 49 - 55 (2000), "ATP Induces c-fos Expression in C6 Glioma Cells by Activation of P-2Y Receptors"
  • 59. Bagley E. E., Vaughan C. W.Christie M. J., J. Physiol., 516, 219 - 225 (1999), "Inhibition by Adenosine Receptor Agonists of Synaptic Transmission in Rat Periaqueductal Grey Neurons"
  • 60. Lewin M. R.Walters E. T., Nature Neurosci., 2, 18 - 23 (1999), "Cyclic GMP Pathway is critical for Inducing Long-term Sensitization of Nociceptive Sensory Neurons"
  • 61. Liao X. G., Gunstream J. D., Lewin M. R., Ambron R. T.Walters E. T., J. Neurosci., 19, 1247 - 1256 (1999), "Activation of Protein Kinase A Contributes to the Expression But not the Induction of Long-term Hyperexcitability Caused by Axotomy of Aplysia Sensory Neurons"
  • 62. Vila-Petroff M. G., Younes A., Egan J., Lakatta E. G.Sollott S. J., Circ. Res., 84, 1020 - 1031 (1999), "Activation of Distinct cAMP-dependent and cGMP-dependent Pathways by Nitric Oxide in Cardiac Myocytes"
  • 63. Leblais V., Demolombe S., Vallette G., Langin D., Baro I., Escande D.Gauthier C., J. Biol. Chem., 274, 6107 - 6113 (1999), "ß3-Adrenoceptor Control the Cystic Fibrosis Transmembrane Conductance Regulator Through a cAMP/Protein Kinase A-independent Pathway"
  • 64. Maronde E., Wicht H., Tasken K., Genieser H.-G., Dehghani F., Olcese J.Korf H.-W., J. Pineal Res., 27, 170 - 182 (1999), "CREB Phosphorylation and Melatonin Biosynthesis in the Rat Pineal Gland: Involvement of cyclic AMP-dependent Protein KinaseType II"
  • 65. Zhou Y. Y., Cheng H., Song L. S., Wang D. J., Lakatta E. G.Xiao R.-P., Mol. Pharmacol., 56, 485 - 493 (1999), "Spontaneous Beta(2)-Adrenergic Signaling Fails to Modulate L-Type Ca2+ Current in Mouse Ventricular Myocytes"
  • 66. Kasyapa C. S., Stentz C. L., Davey M. P.Carr D. W., J. Immunol., 163, 2836 - 2843 (1999), "Regulation of IL-15-Stimulated TNF-Alpha Production by Rolipram"
  • 67. Schubert R., Lehmann G., Serebryakov V. N., Mewes H.Hopp H.-H., Am. J. Physiol.-Heart Circul. Physiol., 46, 1145 - 1155 (1999), "cAMP-Dependent Protein Kinase is in an Active State in Rat Small Arteries Possessing a Myogenic Tone"
  • 68. Luo X., Zeng W., Xu X., Popov S., Davignon I., Wilkie T. M., Mumby S. M.Muallem S., J. Biol. Chem., 274, 17684 - 17690 (1999), "Alternate Coupling of Receptors to G(s) and G(i) in Pancreatic and Submandibular Gland Cells"
  • 69. Han G. C., Kryman J. P., McMillin P. J. P., White R. E.Carrier G. O., J. Cardiovasc. Pharmacol., 34, 619 - 627 (1999), "A Novel Transduction Mechanism Mediating Dopamine-Induced Vascular Relaxation~#~ Opening of BKCa Channels by Cyclic AMP-Induced Stimulation of the Cyclic GMP-Dependent Protein Kinase"
  • 70. Linden D. J.Ahn S., J. Neurosci., 19, 10221 - 10227 (1999), "Activation of Presynaptic cAMP-Dependent Protein Kinase is Required for Induction of Cerebellar Long-Term Potentiation"
  • 71. Liu Y. J., Hellman B.Gylfe E., Endocrinology, 140, 5524 - 5529 (1999), "Ca2+ Signaling in Mouse Pancreatic Polypeptide Cells"
  • 72. Pfeifer A., Ruth P., Dostmann W., Sausbier M., Klatt P.Hofmann F., in Rev. Physiol. Biochem. Pharmacol. Berlin / Springer, 135, 105 - 149 (1999), "Structure and Function of cGMP-Dependent Protein Kinases"
  • 73. Kurjak M., Koppitz P., Schusdziarra V.Allescher H. D., Am. J. Physiol. Gastrointest. Liver Physiol., 277, 875 - 884 (1999), "Evidence for a Feedback Inhibition of NO Synthesis in Enteric Synaptosomes via a Nitrosothiol Intermediate"
  • 74. Kurtz A., Götz K.-H., Hamann M., Kieninger M.Wagner C., Amer. J. Physiol., 43, 709 - 717 (1998), "Stimulation of Renin Secretion by NO Donors is Related to the cAMP Pathway"
  • 75. Vischer U. M.Wollheim C. B., Blood, 91, 118 - 127 (1998), "Purine Nucleotides Induce Regulated Secretion of von Willebrand Factor - Involvement of Cytosolic Ca 2+ and Cyclic Adenosine Monophosphate-dependent Signaling in Endothelial Exocytosis"
  • 76. Money-Kyrle A. R. W., Davies C. H., Ranu H. K., O´gara P., Kent N. S., Poole-Wilson P. A.Harding S. E., Cardiovasc. Res., 37, 532 - 540 (1998), "The Role of cAMP in the Frequency-dependent Changes in Contraction of Guinea-pig Cardiomyocytes"
  • 77. Ingram S. L., Vaughan C. W., Bagley E. E., Connor M.Christie M. J., J. Neurosci., 18, 10269 - 10276 (1998), "Enhanced Opioid Efficacy in Opioid Dependence is Caused by an Altered Signal Transduction Pathway"
  • 78. Hood J.Granger H. J., J. Biol. Chem., 273, 23504 - 23508 (1998), "Protein Kinase G Mediates Vascular Endothelial Growth Factor-induced Raf-1 Activation and Proliferation in Human Endothelial Cells"
  • 79. Braun C. M., Huang S.-K., Kagey-Sobotka A., Lichtenstein L. M.Essayan D. M., Biochem. Pharmacol., 56, 871 - 879 (1998), "Co-Regulation of Antigen-Specific T Lymphocyte Responses by Type I and Type II Cyclic AMP-Dependent Protein Kinases (CAK)"
  • 80. Tasken K., Aandahl E. M., Aukrust P., Müller F., Froland S. S.Hansson V., Intl. Patent Appl. PCT, 0, 0 - 0 (1998), "Use of Immunomodulating Agents"
  • 81. Bonci A.Williams J. T., J. Neurosci., 17, 796 - 803 (1997), "Increased Probability of GABA Release During Withdrawal from Morphine"
  • 82. Maronde E., Middendorff R., Telgmann R., Müller D., Hemmings B., Tasken K.Olcese J., J. Neurochem., 68, 770 - 777 (1997), "Melatonin Synthesis in the Bovine Pineal Gland is Regulated by Type II Cyclic AMP-Dependent Protein Kinase"
  • 83. O'Neil R. G.Leng L., Am. J. Physiol., 273, 120 - 128 (1997), "Osmo-Mechanically Sensitive Phosphatidylinositol Signaling Regulates a Ca²+ Influx Channel in Renal Epithelial Cells"
  • 84. Schubert R., Serebryakov V. N., Mewes H.Hopp H.-H., Amer. J. Physiol.- Heart Circ. Phy., 41, 1147 - 1156 (1997), "Iloprost Dilates Rat Small Arteries - Role of K-ATP- and K-CA-Channel Activation by cAMP-Dependent Protein Kinase"
  • 85. Zhou Y. Y., Cheng H. P., Bogdanov K. Y., Hohl C., Altschuld R., Lakatta E. G.Xiao R. P., Amer. J. Physiol.-Heart Circ. Physiol., 42, 1611 - 1618 (1997), "Localized cAMP-Dependent Signaling Mediates Beta(2)-Adrenergic Modulation of Cardiac Excitation-Contraction Coupling"
  • 86. Maronde E., Schomerus C., Stehle J. H.Korf H.-W., Bio. Cell, 89, 505 - 511 (1997), "Control of CREB Phosphorylation and its Role for Induction of Melatonin Synthesis in Rat Pinealocytes"
  • 87. Wang L., Xu B., White R. E.Lu L., Am. J. Physiol., 273, 1657 - 1665 (1997), "Growth Factor-mediated K+ Channel Activity Associated With Human Myeloblastic ML-1 Cell Proliferation"
  • 88. Yu P.-Y., Eisner G. M., Yamaguchi I., Mouradian M. M., Felder R. A.Jose P. A., J. Biol. Chem., 271, 19503 - 19508 (1996), "Dopamine D-1A Receptor Regulation of Phospholipase C Isoform"
  • 89. Jackson W. F., Pharmacology, 52, 226 - 234 (1996), "Rp Diastereomeric Analogs of cAMP Inhibit Both cAMP-and cGMP-Induced Dilation of Hamster Mesenteric Small Arteries"
  • 90. Boese M., Busse R., Mulsch A.Schini-Kerth V., Br. J. Pharmacol., 119, 707 - 715 (1996), "Effect of cyclic GMP-dependent Vasodilators on the Expression of Inducible Nitric Oxide Synthase in Vascular Smooth Muscle Cells: Role of cyclic AMP"
  • 91. Schubert R., Serebryakov V. N., Engel H.Hopp H.-H., Am. J. Physiol., 271, 1203 - 1211 (1996), "Iloprost Activates Kca Channels of Vascular Smooth Muscle Cells: Role of cAMP-dependent Protein Kinase"
  • 92. Warskulat U., Newsome W., Noe B., Stoll B.Häussinger D., Biol. Chem. Hoppe-Seyler, 377, 57 - 65 (1996), "Anisoosmotic Regulation of Hepatic Gene Expression"
  • 93. Kramer R. H.Tibbs G. R., J. Neurosci., 16, 1285 - 1293 (1996), "Antagonists of Cyclic Nucleotide-gated Channels and Molecular Mapping of their Site of Action"
  • 94. Azula F. J., Alzola E. S., Conde M., Trueba M., Macarulla J. M.Marino A., Mol. Pharmacol., 50, 367 - 379 (1996), "Thrombin-stimulated Phospholipase C Activity is Inhibited Without Visible Delay by a Rapid Increase in the Cyclic GMP Levels Induced by Sodium Nitroprusside"
  • 95. Hemmings H. C., in Regulatory Protein Modification: Techniques and Protocols H.C. Hemmings (ed.) Humana Press Inc., 0, 121 - 218 (1996), "Protein Kinase and Phosphatase Inhibitors. Applications in Neuroscience"
  • 96. Houillier P., Chambrey R., Achard J. M., Froissart M., Poggioli J.Paillard M., Kidney Int., 50, 1496 - 1505 (1996), "Signaling Pathways in the Biphasic Effect of Angiotensin II on Apical NA/H Antiport Activity in Proximal Tubule"
  • 97. Stief C. G., Ückert S., Truss M. C., Becker A. J., Machtens S.Jonas U., Urolog. Res., 24, 333 - 337 (1996), "A Possible Role for Nitric Oxide in the Regulation of Human Uretral Smooth Muscle Tone In Vitro"
  • 98. Salin P. A., Malenka R. C.Nicoll R. A., Neuron, 16, 797 - 803 (1996), "Cyclic AMP Mediates a Presynaptic Form of LTP at Cerebellar Parallel Fiber Synapses"
  • 99. Aoki Y., Albrecht F. E., Bergman K. R.Jose P. A., Amer. J. Physiol., 40, 1561 - 1567 (1996), "Stimulation of Na+ -K+ -2Cl(-) Cotransport in Rat Medullary Thick Ascending Limb by Dopamine"
  • 100. Bito H., Deisseroth K.Tsien R. W., Cell, 87, 1203 - 1214 (1996), "CREB Phosphorylation and Dephosphorylation: A Ca²+- and Stimulus Duration-Dependent Switch for Hippocampal Gene Expression"
  • 101. Jilling T.Kirk K. L., J. Biol. Chem., 271, 4381 - 4387 (1996), "Cyclic AMP and Chloride-Dependent Regulation of the Apical Constitutive Secretory Pathway in Colonic Epithelial Cells"
  • 102. Yu S.-M., Cheng Z.-J.Kuo S.-C., Br. J. Pharmacol., 114, 1227 - 1235 (1995), "Antiproliferative Effects of A02011-1, an Adenylate Cyclase Activator, in Cultured Vascular Smooth Muscle Cells of Rat"
  • 103. Gjertsen B. T., Mellgren G., Otten A., Maronde E., Genieser H.-G., Jastorff B., Vintermyr O. K., McKnight G. S.Doeskeland S. O., J. Biol. Chem., 270, 20599 - 20607 (1995), "Novel (Rp)-cAMPS Analogs as Tools for Inhibition of cAMP-Kinase in Cell Culture"
  • 104. Miserendino M. J. D.Nestler E. J., Brain Res., 674, 299 - 306 (1995), "Behavioral Sensitization to Cocaine: Modulation by the Cyclic AMP System in the Nucleus Accumbens"
  • 105. Roseboom P.Klein D. C., Mol. Pharmacol., 47, 439 - 449 (1995), "Norepinephrine Stimulation of Pineal Cyclic AMP Response Element- Binding Protein Phosphorylation: Primary Role of a ß-Adrenergic Receptor/ Cyclic AMP Mechanism"
  • 106. Genieser H.-G., Proc. 9. Int. Conf. Second Mess. & Phosphoprot. TN USA, 0, 0 - 0 (1995), "Lipophilic Ranking of Biologically Important Cyclic Nucleotides"
  • 107. Weisskopf M. G., Castillo P. E., Zalutsky R. A.Nicoll R. A., Science, 265, 1878 - 1882 (1994), "Mediation of Hippocampal Mossy Fiber Long-term Potentiation by Cyclic AMP"
  • 108. Jastorff B., Maronde E., van Bemmelen M. X. P., Zorn M.Störmann R., Proc. 3rd Intl. Symp. Mol. Aspects Chemother. Poland, PWN Warsaw & Springer Verlag New York, 0, 57 - 87 (1991), "Cyclic Nucleotide Metabolism as a Target in Chemotherapy"
  • 109. Dostmann W. R. G., Taylor S. S., Genieser H.-G., Jastorff B., Doeskeland S. O.Oegreid D., J. Biol. Chem., 265, 10484 - 10491 (1990), "Probing the Cyclic Nucleotide Binding Sites of cAMP-Dependent Protein Kinase I and II with Analogs of Adenosine- 3', 5'- Cyclic Phosphorothioates"

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