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Alternative structural projections:


8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-CPT-cAMPS ), sodium salt
Membrane-permeant and PDE-resistant PKA inhibitor
Cat. No.: C 011
CAS No.: [129735-01-9]
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Product Name Price (net) Qty
Cat. No.: C 011-05
Unit: 5 µmol / ~2.5 mg
highly purified, fluorescent impurities removed. For other salt forms please inquire. Lipophilic analog of Rp-cAMPS (Cat. No. A 002). Potent competitive inhibitor of protein kinase A type I and II (cyclic AMP antagonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Considerably more lipophilic and membrane-permeant compared to Rp-8-Br-cAMPS (Cat. No. B 001). Detailed technical information and updated reference list available on request. Reference: Weisskopf et al., Science, 265, 1878 - 1882 (1994).
Cat. No. C 011
CAS number [129735-01-9]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₆H₁₄ClN₅O₅PS₂ · Na
Molecular weight [g/mol] 509,8
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Modifications 8-cAMP
Target PKA (cAK) Inhibitor
Lipophilicity 2.72
Absorption max [nm] 282
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000