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Rp-8-Br-PET-cGMPS

8- Bromo- β- phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-Br-PET-cGMPS ), sodium salt
Membrane-permeant and PDE-resistant PKG inhibitor
Cat. No.: P 007
    
CAS No.: [172806-20-1]
Technical Information
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Product Name Price (net) Qty
Cat. No.: P 007-01
Unit: 1 µmol / ~0.6 mg
$139.00
For other salt forms please inquire. Selective and membrane-permeant inhibitor of both cyclic GMP dependent protein kinase I a and I ß and of retinal cGMP-gated ion channels. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. More lipophilic and membrane-permeant compared to Rp-8-pCPT-cGMPS (Cat. No. C 013). Detailed technical information and updated reference list available on request. Reference: Butt et. al., Br. J. Pharmacol., 116, 3110 - 3116 (1995).
Cat. No. P 007
Patent Information Protected under patents US 5,625,056 and DE 42 17679 issued to BIOLOG LSI
CAS number [172806-20-1]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₈H₁₄BrN₅O₆PS · Na
Molecular weight [g/mol] 562,3
Modifications 1-cGMP, 2-cGMP, 8-cGMP
Target PKG (cGK) Inhibitor
Lipophilicity 2.83
Absorption max [nm] 256
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 40000
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