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Alternative structural projections:


8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer; immobilized on agarose gel ( Rp-8-AHA-cAMPS-Agarose )
cyclic AMP antagonist immobilized on agarose gel
Cat. No.: A 012
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: A 012-06
Unit: 0.6 ml
Cat. No.: A 012-25
Unit: 2.5 ml
Cat. No.: A 012-60
Unit: 6 ml
The metabolically stable protein kinase A inhibitor Rp-cAMPS (Cat. No. A 002) immobilized on agarose by an aminohexylamino spacer attached to position 8 of the ligand. Free Rp-cAMPS binds to the protein kinase A holoenzyme but prevents dissociation of catalytic and regulatory subunits. In addition it is not hydrolized by mammalian phosphodiesterases. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinase A (presumably as its holoenzyme), phosphodiesterases and others. This ligand is offered with a shorter spacer (Rp-8-AEA-cAMPS-Agarose, Cat. No. A 007) as well. Detailed technical information available. References: Margarucci et al., Mol. BioSyst., 7, 2311 - 2319 (2011); Bertinetti et al., BMC Chem Biol, 9 (2009).Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.
Cat. No. A 012
CAS number [pending]
Storage temperature 4°C / 39°F
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Modifications 8-cAMP