Inhibitor of adenylate cyclase and adenosine deaminase. Antiviral nucleoside which blocks viral reverse transcription from RNA to DNA. Detailed technical information available. Reference: Mitsuya et al., Proc. Natl. Acad. Sci. USA, 84, 2033 - 2037 (1987).
This compound is also part of the Ko-Libri compound library (K 001)
This compound is also part of the Ko-Libri compound library (K 001)
| Cat. No. | D 002 |
| CAS number | [4097-22-7] |
| Purity | > 98% HPLC |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₀H₁₃N₅O₂ |
| Molecular weight [g/mol] | 235.3 |
| Absorption max [nm] | 259 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 15000 |
- 1. Renger J. J., Ueda A., Atwood H. L., Govind C. K.Wu C. F., J. Neurosci., 20, 3980 - 3992 (2000), "Role of cAMP Cascade in Synaptic Stability and Plasticity: Ultrastructural and Physiological Analyses of Individual Synaptic Boutons in Drosophila Memory Mutants"
- 2. Suzuki S., Lee B., Luo W., Tovell D., Robins M. J.Tyrrell D. L. J., Biochem. Biophys. Res. Commun., 156, 1144 - 1151 (1988), "Inhibition of Duck Hepatitis B Virus Replication by Purine 2',3'-Dideoxynucleosides"
- 3. Mitsuya H., Jarrett R. F., Matsukura M., Di Marzo Veronese F., De Vico A. L., Sarngadharan M. G., Johns D. G., Reitz M. S.Broder S., Proc. Natl. Acad. Sci. USA, 84, 2033 - 2037 (1987), "Long-Term Inhibition of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus (Human Immunodeficiency Virus) DNA Synthesis and RNA Expression in T Cells Protected by 2',3'-Dideoxynucleosides in Vitro"
