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Potential metabolite of 8-chloro cyclic AMP (Cat. No. C 007) and 8- chloroadenosine (Cat. No. C 006), respectively. Detailed technical information available. Reference: Lange-Carter et al., Cancer Res., 53, 393 - 400 (1993). This compound is also part of the Ko-Libri compound library (K 001)
Cat. No.
C 019
CAS number
[116285-77-9]
Purity
> 98% HPLC
Storage temperature
-20°C / -4°F
Molecular formula
C₁₀H₁₁ClN₄O₅
Molecular weight [g/mol]
302.7
Absorption max [nm]
252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]
10500
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2. Gandhi V., Ayres M., Halgren R. G., Krett N. L., Newman R. A.Rosen S. T., Cancer Res., 61, 5474 - 5479 (2001), "8-Chloro-cAMP and 8-Chloro-Adenosine Act by the Same Mechanism in Multiple Myeloma Cells"
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5. Vintermyr O. K., Böe R., Brustugun O. T., Maronde E., Aakvaag A.Doeskeland S. O., Endocrinology, 136, 2513 - 2520 (1995), "Cyclic Adenosine Monophosphate (cAMP) Analogs 8-Cl- and 8-NH(2)-cAMP Induce Cell Death Independently of cAMP Kinase-Mediated Inhibition of the G(1)/S Transition in Mammary Carcinoma Cells (MCF-7)"
6. Langeveld C. H., Jongenelen C. A. M., Heimans J. J.Stoof J. C., Cancer Res., 52, 3994 - 3999 (1992), "Growth Inhibition of Human Glioma Cells Induced by 8-Chloroadenosine, an Active Metabolite of 8-Chloro Cyclic Adenosine 3':5'- Monophosphate"
7. Lange-Carter C. A., Vuillequez J. J.Malkinson A. M., Cancer Res., 53, 393 - 400 (1992), "8-Chloroadenosine Mediates 8-Chloro-Cyclic AMP-Induced Down- Regulation of Cyclic AMP-dependent Protein Kinase in Normal and Neoplastic Mouse Lung Epithelial Cells by a Cyclic AMP-independent Mechanism"
8. Han Z., Chatterjee D.Wyche J. H., J. Pharmacol. Exp. Ther., 265, 790 - 794 (1992), "Proliferation of Nontransformed Cells is Inhibited by Adenosine Metabolite of But Not by Parental 8-Cl-Cyclic AMP"