7-CN-7-C-Ino is a potent and highly specific activator of the cAMP-independent trypanosomal protein kinase A (in Trypanosoma brucei EC50 6.5 ± 4.6 nM on the purified holoenzyme, KD 8 ± 2 nM to the regulatory subunit PKAR) that has low toxicity in vivo (Bachmaier et al., Nat. Commun., 10(1):1421 (2019)). It was also described as a naturally occuring metabolite, called Jaspamycin, isolated from the marine sponge Jaspis splendens (Wang et al., J. Nat. Prod., 79, 353 - 361 (2016)).
| Cat. No. | C 214 |
| CAS number | [22242-96-2] |
| Purity | > 98% HPLC |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₂H₁₂N₄O₅ |
| Molecular weight [g/mol] | 292.3 |
| Target | PKA (cAK) Activator |
| Absorption max [nm] | 275 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 10800 |
| UV pH value | 11 |
