Potential substrate, competitive inhibitor or regulator of enzymes that interact with 2'-deoxyadenosine-5'-monophosphate. Can be modified with SH-reactive reporters or linked to structures with SH-groups via a disulfide bond. Detailed technical information available. Reference: Vosberg & Eckstein, J. Biol. Chem., 257, 6595 - 6599 (1982).
| Cat. No. | D 003 |
| CAS number | [64145-26-2] |
| Purity | > 97% HPLC |
| Salt form | Sodium |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₀H₁₄N₅O₅PS (free acid) |
| Molecular weight [g/mol] | 347.3 (free acid) |
| Absorption max [nm] | 259 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 15200 |
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- 2. Gupta A., DeBrosse C.Benkovic S. J., J. Biol. Chem., 257, 7689 - 7692 (1982), "Template-Primer-dependent Turnover of (Sp)-dATP@S by T4 DNA Polymerase"
- 3. Vosberg H.-P.Eckstein F., J. Biol. Chem., 257, 6595 - 6599 (1982), "Effect of Deoxynucleoside Phosphorothioates Incorporated in DNA on Cleavage by Restriction Enzymes"
- 4. Brody R. S.Frey P. A., Biochemistry, 20, 1245 - 1252 (1981), "Unambigous Determination of the Stereochemistry of Nucleotidyl Transfer Catalyzed by DNA Polymerase I from Escherichia coli"
- 5. Burgers P. M. J.Eckstein F., J. Biol. Chem., 254, 6889 - 6893 (1979), "A Study of the Mechanism of DNA Polymerase I from Escherichia coli with Diastereomeric Phosphorothioate Analogs of Deoxyadenosine Triphosphate"
- 6. Vosberg H.-P.Eckstein F., Biochemistry, 16, 3633 - 3640 (1977), "Incorporation of Phosphorothioate Groups into fd and phiX174 DNA"
