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Potential cytotoxic metabolite of Cladribine (Cat. No. C 028), Clofarabine, 2-Cl-cAMP (Cat. No. C 020) and 2- chloroadenosine (Cat. No. C 017), respectively. Detailed technical information available. Reference: Bontemps et al., Biochem Pharmacol., 59, 1237 - 1243 (2000).
Cat. No.
C 040
CAS number
[1839-18-5]
Purity
> 95% HPLC
Storage temperature
-20°C / -4°F
Molecular formula
C₅H₄ClN₅
Molecular weight [g/mol]
169.6
Absorption max [nm]
263
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]
14000
1. Chevassus H., Roig A., Belloc C., Lajoix A. D., Broca C., Manteghetti M.Petit P., Naunyn-Schmiedebergs Arch. Pharmacol., 366, 464 - 469 (2002), "P2Y Receptor Activation Enhances Insulin Release from Pancreatic Beta-cells by Triggering the Cyclic AMP/Protein Kinase A Pathway"
2. Bontemps F., Delacauw A., Cardoen S., Van Den Neste E.Van den Berghe G., Biochem Pharmacol., 59, 1237 - 1243 (2000), "Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-2'-deoxyadenosine"