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Biomarker for analysis of chlorine stressed DNA / RNA and potential metabolite of 8-chloroadenosine (Cat. No. C 006) and 8-Cl-cAMP (Cat. No. C 007). Detailed technical information available. References: Han et al., J. Pharmacol. Exper. Ther., 265, 790 - 794 (1992); Whiteman at al., Biomarkers4, 303 - 310 (1999). This compound is also part of the Ko-Libri compound library.
Cat. No.
C 023
CAS number
[28128-28-1]
Purity
> 95% HPLC
Storage temperature
-20°C / -4°F
Molecular formula
C₅H₄ClN₅
Molecular weight [g/mol]
169.6
Absorption max [nm]
268
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]
17000
1. Gandhi V., Chen W., Ayres M., Rhie J. K., Madden T. L.Newman R. A., Cancer Chemother. Pharmacol., 50, 85 - 94 (2002), "Plasma and Cellular Pharmacology of 8-Chloro-Adenosine in Mice and Rats"
2. Whiteman M., Jenner A.Halliwell B., Biomarkers, 4, 303 - 310 (1999), "8-Chloroadenine: A Novel Product Formed from Hypochlorous Acid-induced Damage to Calf Thymus DNA"
3. Kozlowska M., Smolenski R. T., Makarewicz W., Hoffmann C., Jastorff B.Swierczynski J., Toxicol. Lett., 104, 171 - 181 (1999), "ATP Depletion, Purine Riboside Triphosphate Accumulation and Rat Thymocyte Death Induced by Purine Riboside"
4. Vintermyr O. K., Böe R., Brustugun O. T., Maronde E., Aakvaag A.Doeskeland S. O., Endocrinology, 136, 2513 - 2520 (1995), "Cyclic Adenosine Monophosphate (cAMP) Analogs 8-Cl- and 8-NH(2)-cAMP Induce Cell Death Independently of cAMP Kinase-Mediated Inhibition of the G(1)/S Transition in Mammary Carcinoma Cells (MCF-7)"
5. Han Z., Chatterjee D.Wyche J. H., J. Pharmacol. Exp. Ther., 265, 790 - 794 (1992), "Proliferation of Nontransformed Cells is Inhibited by Adenosine Metabolite of But Not by Parental 8-Cl-Cyclic AMP"
6. Jastorff B.Freist W., Bioorg. Chem., 3, 103 - 113 (1974), "Synthesis and Biological Activities of cyclic AMP Analogs Modified in the 1, 2 and 2'- Positions"