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m2,2,7G/TMG

N², N², 7- Trimethylguanosine ( m2,2,7G / TMG )
Cat. No.: T 009
    
CAS No.: [40027-70-1]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: T 009-05
Unit: 5 µmol / ~1.6 mg
$212.00

5' cap nucleoside of small nuclear RNAs. N2, N2- Dimethylguanosine is offered as well (Cat. No. D 016). Detailed technical information available. References: Reddy et al., J. Biol. Chem., 247, 7245 - 7250 (1972); Bahia et al., Nucleosides Nucleotides Nucleic Acids, 25, 909 - 923 (2006); Liou & Blumenthal, Mol. Cell. Biol., 10, 1764 - 1768 (1990).

Cat. No. T 009
CAS number [40027-70-1]
Purity > 95% HPLC
Salt form internal salt
Storage temperature -20°C / -4°F
Molecular formula C₁₃H₁₉N₅O₅
Molecular weight [g/mol] 325,3 (internal salt)
Absorption max [nm] 267
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 13800
UV pH value 5
  • 1. Bullinger D., Neubauer H., Fehm T., Laufer S., Gleiter C. H.Kammerer B., BMC Biochemistry, 8, 1 - 14 (2007), "Metabolic Signature of Breast Cancer Cell Line MCF-7: Profiling of Modified Nucleosides via LC-IT MS Coupling"
  • 2. Bahia D., Avino A., Darzynkiewicz E., Eritja R.Bach-Elias M., Nucleosides Nucleotides Nucleic Acids, 25, 909 - 923 (2006), "Trimethylguanosine Nucleoside Inhibits Cross-Linking Between Snurportin 1 and m3G-CAPPED U1 snRNA"
  • 3. Wieczorek Z., Stepinski J., Jankowska M.Lönnberg H., J. Photochem. Photobiol. B, 28, 57 - 63 (1995), "Fluorescence and Absorption Spectroscopic Properties of RNA 5'-Cap Analogues Derived from 7-Methyl-, N2,7-Dimethyl- and N2,N2,7-Trimethyl-guanosines"
  • 4. Liou R.-F.Blumenthal T., Mol. Cell. Biol., 10, 1764 - 1768 (1990), "Trans-Spliced Caenorhabditis Elegans mRNAs Retain Trimethylguanosine Caps"
  • 5. Reddy R., Ro-Choi T. S., Henning D., Shibata H., Choi Y. C.Busch H., J. Biol. Chem., 247, 7245 - 7250 (1972), "Modified Nucleosides of Nuclear and Nucleolar Low Molecular Weight Ribonucleic Acid"