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8-Br-TNP-ITP

8- Bromo- 2', 3'- O- (2, 4, 6- trinitrophenyl)inosine- 5'- O- triphosphate ( 8-Br-TNP-ITP )
Fluorescent ITP analogue
Cat. No.: B 186
    
CAS No.: [pending]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: B 186-01
Unit: 1 µmol / ~0.8 mg
$145.00

For other salt forms please inquire. Fluorescent analogue of ATP and GTP, respectively with λexc 408 nm and λem 552 nm, which is supposed to substitute for ATP and GTP in the interaction with various enzymes and proteins. It is sensitive to indicators of local environment such as polarity and viscosity, and frequently exhibits a spectral shift and fluorescence enhancement upon binding to a protein. Potential inhibitor of various adenylyl cyclase isoforms and soluble guanylyl cyclase (sGC). References for the related TNP-GTP: Hiratsuka, T., J. Biol. Chem.260, 4784 - 4790 (1985), and various TNP-NTPs: Suryanarayana et al., J. Pharmacol. Exp. Ther.330, 687 - 695 (2009).

 

Vial containing 1 ml of 1 mM aqueous solution of pH 8.

Cat. No. B 186
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Appearance 1 mM aqueous solution
Storage temperature -70°C / -94°F
Light-sensitive Yes
Molecular formula C₁₆H₁₅BrN₇O₂₀P₃ (for free acid)
Molecular weight [g/mol] 798.2 (for free acid)
Excitation max [nm] 408
Emission max [nm] 552
Absorption max [nm] 408
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 26500
UV pH value 8
Solvent for UV data 0.1 M Tris-HCl