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2-MeS-TNP-ITP

2- Methylthio- 2', 3'- O- (2, 4, 6- trinitrophenyl)inosine- 5'- O- triphosphate ( 2-MeS-TNP-ITP )
Fluorescent ITP analogue
Cat. No.: M 124
    
CAS No.: [pending]
Shipping: Dry ice

For other salt forms please inquire. Fluorescent analogue of ATP and GTP, respectively with λexc 408 nm and λem 552 nm, which is supposed to substitute for ATP and GTP in the interaction with various enzymes and proteins. Potential agonist of P2Y purinoceptors and supposed to be inhibitor of soluble guanylate cyclase. It is sensitive to indicators of local environment such as polarity and viscosity, and frequently exhibits a spectral shift and fluorescence enhancement upon binding to a protein. References for the related TNP-GTP: Hiratsuka, T., J. Biol. Chem., 260, 4784 - 4790 (1985), and various TNP-NTPs: Suryanarayana et al., J. Pharmacol. Exp. Ther., 330, 687 - 695 (2009). Reference for 2-MeS-ATP: Ruiz-Stewart et al., Eur. J. Biochem., 269, 2186 - 2193 (2002).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 8

 


The category "Future Products" lists structures that are already "in the pipeline" and nearly ready to be offered as regular products. Please just inquire, your interest will certainly accelerate the process.

Cat. No. M 124
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Appearance 1 mM aqueous solution
Storage temperature -70°C / -94°F
Light-sensitive Yes
Molecular formula C₁₇H₁₈N₇O₂₀P₃S (for free acid)
Molecular weight [g/mol] 765.4 (for free acid)
Excitation max [nm] 408
Emission max [nm] 552
Absorption max [nm] 408
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 26500
UV pH value 8
Solvent for UV data 0.1 M Tris-HCl