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ESI-05

4- Methylphenyl- 2, 4, 6- trimethylphenylsulfone ( ESI-05 )
Membrane-permeant, selective inhibitor of Epac 2
Cat. No.: M 092
    
CAS No.: [5148-64-5]
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Product Name Price (net) Qty
Cat. No.: M 092-05
Unit: 5 µmol / ~1.4 mg
$190.00
According to Tsalkova et al. (2012) ESI-05 is a membrane-permeant selective inhibitor of Epac 2. Detailed technical information available. Reference: Tsalkova et al., Proc. Natl. Acad. USA, 109, 18613 - 18618 (2012).
Cat. No. M 092
CAS number [5148-64-5]
Purity > 95% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₁₈O₂S
Molecular weight [g/mol] 274,4
Target Epac Inhibitor
Absorption max [nm] 244
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 19000
  • 1. Henquin J.-C.Nenquin M., Endocrinol., 0, 0 - 0 (2014), "Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca2+ in Female Mouse Islets Stimulated by Glucose and Tolbutamide"
  • 2. Rehmann H., Sci. Rep., 3: 3032, 0, 0 - 0 (2013), "Epac-Inhibitors: Facts and Artefacts"
  • 3. Tsalkova T., Mei F. C., Li S., Chepurny O. G., Leech C. A., Liu T., Holz G. G., Woods V. L.Cheng X., Proc. Natl. Acad. Sci. USA, 109, 18613 - 18618 (2012), "Isoform-Specific Antagonists of Exchange Proteins Directly Activated by cAMP"