According to Chen et al. (2012) HJC0197 is a membrane-permeant inhibitor of Epac 1 and Epac 2. Detailed technical information available. Reference: Chen et al., Bioorg. Med. Chem. Lett., 22, 4038 - 4043 (2012).
| Cat. No. | C 136 |
| CAS number | [1383539-73-8] |
| Purity | > 95% HPLC |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₉H₂₁N₃OS |
| Molecular weight [g/mol] | 339.5 |
| Target | Epac Inhibitor |
| Absorption max [nm] | 304 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 14700 |
- 1. Rehmann H., Sci. Rep., 3: 3032, 0, 0 - 0 (2013), "Epac-Inhibitors: Facts and Artefacts"
- 2. Chen H., Tsalkova T., Mei F. C., Hu Y., Cheng X.Zhou J., Bioorg. Med. Chem. Lett., 22, 4038 - 4043 (2012), "5-Cyano-6-Oxo-1,6-Dihydro-Pyrimidines as Potent Antagonists Targeting Exchange Proteins Directly Activated by cAMP"
