Thymidine analogue of interest in antiviral research. Inhibits DNA polymerase ß and thymidine kinase. Detailed technical information available. References: Yamanaka et al., Biol. Pharmaceut. Bull., 20, 163 - 167 (1997); Seiser et al., J. Mol. Biol., 265, 153 - 160 (1997).
This compound is also part of the Ko-Libri compound library (K 001)
This compound is also part of the Ko-Libri compound library (K 001)
| Cat. No. | D 040 |
| CAS number | [3416-05-5] |
| Purity | > 98% HPLC |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₀H₁₄N₂O₄ |
| Molecular weight [g/mol] | 226.2 |
| Absorption max [nm] | 267 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 9600 |
- 1. Sutterluety H.Seiser C., J. Mol. Biol., 265, 153 - 160 (1997), "Thymidine Inhibits the Growth-Arrest-Specific Degradation of Thymidine Kinase Protein in Transfected L Fibroblasts"
- 2. Yamanaka K., Hayashi H., Kato K., Hasegawa A., Oku N.Okada S., Biol. Pharm. Bull., 20, 163 - 167 (1997), "DNA Single-Strand Breaks in L-132 Cells Resulting from Inhibition of Repair Polymerization Shortly after Exposure to Dimethylarsinic Acid"
- 3. Buzayan J. M., Feldstein P. A., Segrelles C.Bruening G., Nucleic Acids Res., 16, 4009 - 4023 (1988), "Autolytic Processing of a Phosphorothioate Diester Bond"
- 4. Suzuki S., Lee B., Luo W., Tovell D., Robins M. J.Tyrrell D. L. J., Biochem. Biophys. Res. Commun., 156, 1144 - 1151 (1988), "Inhibition of Duck Hepatitis B Virus Replication by Purine 2',3'-Dideoxynucleosides"
