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Proteolytically resistant, membrane permeant and highly potent peptide-based inhibitor of protein kinase G type I α and I β. Detailed technical information available. Reference: Nickl et al., Biochim. Biophys. Acta, 1804, 524 - 532 (2010). Biolog also offers the control peptide W45 (Cat. No. W 001).
Cat. No.
D 110
CAS number
[pending]
Purity
> 95% HPLC
Salt form
TFA
Storage temperature
-20°C / -4°F
Molecular formula
C₁₂₂H₂₂₃N₅₃O₂₃
Molecular weight [g/mol]
2800.5 for free peptide
1. Gambaryan S., Butt E., Kobsar A., Geiger J., Rukoyatkina N., Parnova R., Nikolaev V. O.Walter U., Br. J. Pharmacol., 167, 1476 - 5381 (2012), "The Oligopeptide DT-2 is a Specific PKG I Inhibitor only In Vitro, not in Living Cells"
2. Gambaryan S., Butt E., Geiger J., Lohmann S. M.Walter U., BMC Pharmacol., Suppl. 1, P27, 11, 0 - 0 (2011), "Specific PKG Inhibitors: Do They Really Exist?"
3. Nickl C. K., Raidas S. K., Zhao H., Sausbier M., Ruth P., Tegge W., Brayden J. E.Dostmann W. R. G., Biochim. Biophys. Acta, 1804, 524 - 532 (2010), "(D)-Amino Acid Analogues of DT-2 as Highly Selective and Superior Inhibitors of cGMP-dependent Protein Kinase I alpha"