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  1. cGMP modified at the exocyclic oxygen: equatorial (Rp-)
Lipophilicity

Lipophilicity ranking is based on log kw data. To be membrane-permeant, analogues should have a log kw of at least 1.2
See also: Lipophilic Ranking of Cyclic Nucleotide Analogs

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PDE- resistant PKG Inhibitors

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