Membrane-permeant precursor of the PDE-resistant protein kinase A activator
Sp-cAMPS. Metabolic bioactivation by esterases releases the active analogue, which is trapped inside the cell. Chemical hydrolysis can produce some cyclic AMP as well. Detailed technical information available. Reference: Maronde et al.,
J. Pineal Res.,
31, 183 - 185 (2001). Vanhoose et al.,
J. Neurosci.,
26, 1138 - 1145 (2006). Biolog also offers
Phosphate tris(acetoxymethyl)ester (PO
4-AM
3,
Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.