Extremely membrane-permeant precursor of the specific Epac agonist 8-pCPT-2'-O-Me-cAMP (Cat. No. C 041). After permeation and metabolic activation by esterases the active compound 8-pCPT-2'-O-Me-cAMP is released. References: Vliem et al., ChemBioChem, 9, 2052 - 2054 (2008); Chepurny et al., J. Biol. Chem., 284, 10728 - 10736 (2009); Chepurny et al., Am. J.Physiol., 298, E622 - E633 (2010).
Related products: Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications. 6-Bnz-cAMP-AM (Cat. No. B 079) is a highly membrane-permeant specific activator of PKA and can be used as Epac-negative control.
Cat. No. | C 051 |
CAS number | [1152197-23-3] |
Purity | > 97% HPLC for mixture of isomers |
Storage temperature | -20°C / -4°F |
Molecular formula | C₂₀H₂₁ClN₅O₈PS |
Molecular weight [g/mol] | 557.9 |
Modifications | 8-cAMP, 2'-cAMP |
Target | Epac Activator |
Absorption max [nm] | 282 |
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 16000 |