Alternative structural projections:
For other salt forms please inquire. 8-N3-6-[DY-547]-AE-cAMP is a light sensitive analogue for photoaffinity labelling. It can be immobilized within a cyclic AMP binding site by illumination with UV light. The fluorescent reporter group connected to position 6 of the adenine nucleobase can be excitated at 557 nm and emits with 574 nm. Detailed technical information available. Reference: Park et al., Cell, 148, 421 - 433 (2012).
| Cat. No. | A 100 |
| CAS number | [pending] |
| Purity | > 95% HPLC |
| Salt form | Sodium |
| Storage temperature | -20°C / -4°F |
| Light-sensitive | True |
| Molecular formula | C₄₂H₄₈N₁₁O₁₃PS₂ · Na₂ |
| Molecular weight [g/mol] | 1056 |
| Modifications | 8-cAMP |
| Target | PKA (cAK) Activator |
| Excitation max [nm] | 557 |
| Emission max [nm] | 574 |
| Absorption max [nm] | 559 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 150000 |
| Solvent for UV data | EtOH |
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- 2. Miyoshi K., Kawakami N., Horio S.Fukui H., Methods Find. Exp. Clin. Pharmacol., 25, 343 - 347 (2003), "Inhibition of Histamine hi Receptor Downregulation by KT5823, a Protein Kinase G Inhibitor"
- 3. Bryce P. J., Dascombe M. J.Hutchinson I. V., Immunopharmacology, 41, 139 - 146 (1999), "Immunomodulatory Effects of Pharmacological Elevation of Cyclic AMP in T Lymphocytes Proceed Via a Protein Kinase A Independent Mechanism"
