Membrane-permeant, metabolically activatable prodrug form of the potential further second messenger cyclic UMP (
cUMP, Cat. No. U 001). After permeation and metabolic activation by esterases the polar cUMP is released which is trapped inside the cell and subsequently metabolized quickly, resulting in a pulse-type signal. Detailed technical information available. Reference: Beckert et al.,
Biochem. Biophys. Res. Commun.,
451, 497 - 502 (2014).
Biolog also offers Phosphate tris(acetoxymethyl)ester (
PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.