Highly membrane-permeant precursor of the PKA activator 8-Br-cAMP (Cat. No. B 007). Metabolic activation by esterases releases the polar active analogue, which is trapped inside the cell. Detailed technical information available. References: Kruppa et al.,
Bioorg. Med. Chem. Lett.,
7, 945 - 948 (1997); Krakstad et al.,
J. Leukocyte Biol.,
76, 641 - 647 (2004); Moll et al.,
J. Neural. Transm.,
113, 1015 - 1032 (2006).
Biolog also offers
Phosphate tris(acetoxymethyl)ester (PO
4-AM
3,
Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.