Equatorial isomer. BCMCM-caged 8-Br-cGMP is an only weakly fluorescent, caged precursor of 8-bromo cyclic cGMP, which upon irradiation, releases both 8-Br-cGMP and a fluorescent coumarin analogue. Excellent solubility in water or buffers. Detailed technical information available. For reference please compare: Hagen et al., Angew. Chem. Int. Ed., 40, 1046 - 1048 (2001).
| Cat. No. | B 019 |
| CAS number | [370091-68-2] |
| Purity | > 98% HPLC |
| Storage temperature | -20°C / -4°F |
| Light-sensitive | True |
| Molecular formula | C₂₄H₂₁BrN₅O₁₅P x 3 H₂O |
| Molecular weight [g/mol] | 784.4 |
| Modifications | 8-cGMP |
| Target | PKG (cGK) Activator |
| Absorption max [nm] | 346 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 11200 |
- 1. Hagen V., Benndorf K.Kaupp U. B., aus: Dynamic Studies in Biology - Phototriggers R. Givens) Wiley-VCH Verlag Weinheim, 0, 0 - 0 (2005), "Photochemical Release of Second Messengers - Caged Cyclic Nucleotides"
- 2. Kaupp U. B.Seifert R., Physiol. Rev., 82, 769 - 824 (2002), "Cyclic Nucleotide-Gated Ion Channels"
- 3. Hagen V., Bendig J., Frings S., Eckardt T., Helm S., Reuter D.Kaupp U. B., Angew. Chem. Int. Ed., 40, 1046 - 47 (2001), "Highly Efficient and Ultrafast Phototriggers for cAMP and cGMP by Using Long-Wavelength UV/Vis-Activation"
- 4. Hagen V., Kaupp U. B., Bendig J.Wiesner B., Deutsche Offenlegungsschrift of 20.04.2000, 0, 0 - 0 (2000), "Neue, photolabile Cumarinylmethylester von cyclischen Nucleotiden, Verfahren zu deren Herstellung und ihre Verwendung"
