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cCMP

Cytidine- 3', 5'- cyclic monophosphate ( cCMP ), sodium salt
Potential second messenger
Cat. No.: C 001
    
CAS No.: [54925-33-6]
Technical Information
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 001-50
Unit: 50 µmol / ~16 mg
$106.00
For other salt forms, more PDE-resistant and membrane-permeant analogues please inquire. Potential further second messenger. Detailed technical information available. Reference: Newton, Nucleosides & Nucleotides 14, 743 - 747 (1995); Desch et al., FEBS Lett., 584, 3979 - 3984 (2010); Reinecke et al., FEBS Lett., 585, 3259 - 3262 (2011).
Cat. No. C 001
CAS number [54925-33-6]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₉H₁₁N₃O₇P · Na
Molecular weight [g/mol] 327,2
Lipophilicity 0.63
Absorption max [nm] 270
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 9000
  • 1. Bähre H., Hartwig C., Munder A., Wolter S., Stelzer T., Schirmer B., Beckert U., Frank D. W., Tümmler B., Kaever V.Seifert R., Biochem. Biophys. Res. Commun., 460, 909 - 914 (2015), "cCMP and cUMP Occur in Vivo"
  • 2. Beste K. Y., Spangler C. M., Burhenne H., Koch K.-W., Shen Y., Tang W.-J., Kaever V.Seifert R., PLoS ONE, 8, 0 - 0 (2013), "Nucleotidyl Cyclase Activity of Particulate Guanylyl Cyclase A: Comparison with Particulate Guanylyl Cyclases E and F, Soluble Guanylyl Cyclase and Bacterial Adenylyl Cyclases Cyaa and Edema Factor"
  • 3. Jäger R., Russwurm C., Schwede F., Genieser H.-G., Koesling D.Russwurm M., J. Biol. Chem., 287, 1210 - 1219 (2012), "Activation of PDE10 and PDE11 Phosphodiesterases"
  • 4. Hammerschmidt A., Chatterji B., Zeiser J., Schröder A., Genieser H.-G., Pich A., Kaever V., Schwede F., Wolter S.Seifert R., PLoS ONE, 7, 39848 - 0 (2012), "Binding of Regulatory Subunits of cyclic AMP-dependent Protein Kinase to cyclic CMP Agarose"
  • 5. Zong X., Krause S., Chen C.-C., Krüger J., Gruner C., Cao-Ehlker X., Fenske S., Wahl-Schott C.Biel M., J. Biol. Chem., 287, 26506 - 26512 (2012), "Regulation of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Activity by cCMP"
  • 6. Reinecke D., Burhenne H., Sandner P., Kaever V.Seifert R., FEBS Lett., 585, 3259 - 3262 (2011), "Human Cyclic Nucleotide Phosphodiesterases Possess a Much Broader Substrate-Specificity than Previously Appreciated"
  • 7. Desch M., Schinner E., Kees F., Hofmann F., Seifert R.Schlossmann J., FEBS Lett., 584, 3979 - 3984 (2010), "Cyclic Cytidine 3',5'-Monophosphate (cCMP) Signals via cGMP Kinase I"
  • 8. Göttle M., Dove S., Kees F., Schlossmann J., Geduhn J., König B., Shen Y., Tang W.-J., Kaever V.Seifert R., Biochemistry, 49, 5494 - 5503 (2010), "Cytidylyl and Uridylyl Cyclase Activity of Bacillus anthracis Edema Factor and Bordetella pertussis CyaA"
  • 9. Scott S.-P., Shea P. W.Dryer S. E., Biochem., 46, 9417 - 9431 (2007), "Mapping Ligand Interactions with the Hyperpolarization Activated Cyclic Nucleotide Modulated (HCN) Ion Channel Binding Domain Using a Soluble Construct"
  • 10. Abadi R. H. H. B., Anal. Biochem., 312, 91 - 100 (2003), "Nucleotide Profile of Mouse Liver: Response to 2'-O-Dibutyryl Cytidine 3',5'-Cyclic Monophosphate"
  • 11. Richards H., Das S., Smith C. J., Pereira L., Geisbrecht A., Devitt N. J., Games D. E., van Geyschem J., Brenton A. G.Newton R. P., Phytochemistry, 61, 531 - 537 (2002), "Cyclic Nucleotide Content of Tobacco BY-2 Cells"
  • 12. Lin S.-H., Kovac L., Chin A. J., Chin C. C. Q.Lee J. C., Biochemistry, 41, 2946 - 2955 (2002), "Ability of E. Coli Cyclic AMP Receptor Protein To Differentiate Cyclic Nucleotides: Effects of Single Site Mutations"
  • 13. Balint G. A., Galfi M., Rimanoczy A., Falkay G.Juhaaz A., J. Physiol.-Paris, 95, 243 - 245 (2001), "On a Possible New Intracellular Signal-System in Rat Gastric Mucosa"
  • 14. Honda A., Adams S. R., Sawyer C. L., Lev-Ram V., Tsien R. Y.Dostmann W. R. G., PNAS, 98, 2437 - 2442 (2001), "Spatiotemporal Dynamics of Guanosine 3'5'-cyclic -Monophosphate Revealed by a Genetically Encoded, Fluorescent Indicator"
  • 15. Koizumi M.Breaker R. R., Biochemistry, 39, 8983 - 8992 (2000), "Molecular Recognition of cAMP by an RNA Aptamer"
  • 16. Nikolakaki E., Fissentzidis A., Giannakouros T.Georgatsos J. G., Mol. Cell. Biochem., 197, 117 - 128 (1999), "Purification and Characterization of a Dimer Form of the cAMP-dependent Protiein Kinase from Mouse Liver Cytosol"
  • 17. Dousa T. P., Kidney Int., 55, 29 - 62 (1999), "Cyclic 3',5'- Nucleotide Phosphodiesterase Isozymes in Cell Biology and Pathophysiology of the Kidney"
  • 18. Newton R. P., Nucleos. Nucleot., 17, 1009 - 1018 (1998), "Quantitation of Cytidine 3',5'- Cyclic Monophosphate in Aqueous Solution by UV Absorption Spectrometry Independent of Direct Determination of Solution pH"
  • 19. Riegel J. A., Maddrell S. H. P., Farndale F. W.Caldwell F. M., J. Exp. Biol., 201, 3411 - 3418 (1998), "Stimulation of Fluid Secretion of Malpighian Tubules of Drosophila Melanogaster Meig. by Cyclic Nucleotides of Inosine, Cytidine, Thymidine and Uridine"
  • 20. Hebert M. C., Schwede F., Jastorff B.Cote R. H., J. Biol. Chem., 273, 5557 - 5565 (1998), "Structural Features of the Noncatalytic cGMP Binding Sites of Frog Photoreceptor Phoshodiesterase Using cGMP Analogs"
  • 21. Newton R. P., Groot N., van Geyschem J., Diffley P. E., Walton T. J., Bayliss M. A., Games D. E.Brenton A. G., Rap. Commun. Mass Spectr., 11, 189 - 194 (1997), "Estimation of Cytidylyl Cyclase Activity and Monitoring of Side-product Formation by Fast-atom Bombardment Mass Spectrometry"
  • 22. Newton R. P., in Proceedings of the Phytochemical Society of Europe (R.P.Newton/T.J.Walton Clarendon Press Oxford, 0, 158 - 181 (1996), "11. Mass Spectrometric Analysis of Cyclic Nucleotides and Related Enzymes"
  • 23. Worby A., Mensah L. M.Murray K. J., Biochem. Pharmacol., 42, 1318 - 1321 (1991), "Identification of the Novel Rat Liver IBMX-insensitive Phosphodiesterase as a Non-specific Phosphodiesterase Capable of Hydrolysing cCMP"
  • 24. Ervens J.Seifert R., Biochem. Biophys. Res. Commun., 174, 258 - 267 (1991), "Differential Modulation by N4,2'-O-Dibutyryl Cytidine 3':5'-cyclic Monophosphate of Neutrophil Activation"
  • 25. Newton R. P., Salih S. G.Khan J. A., Cyclic Nucleotide Phosphodiesterases: Structure M.D. Houslay ed., Wiley Interscience Chichester UK, 17, 141 - 159 (1990), "Cyclic CMP-Specific Phosphodiesterase Activity"
  • 26. Shanahan M. F.Edwards B. M., Endocrinology, 125, 1074 - 1081 (1989), "Stimulation of Glucose Transport in Rat Cardiac Myocytes by Guanosine-3',5'-Cyclic-Monophosphate"
  • 27. Eckstein F.Kutzke U., Tetrahedron Lett., 27, 1657 - 1660 (1986), "Synthesis of Nucleoside 3',5'- Cyclic Phosphorothioates"
  • 28. Kingston E. E., Beynon J. H.Newton R., Biomedical Mass Spectrometry, 11, 367 - 374 (1984), "The Identification of Cyclic Nucleotides from Living Systems Using Collison-induced Dissociation of Ions Generated by Fast Atom Bombardment Mass Spectrometry"
  • 29. Varughese K. I., Lu C. T.Kartha G., J. Am. Chem. Soc., 104, 3398 - 3401 (1982), "The Crystal and Molecular Structure of Cyclic Adenosine 3', 5'- Monophosphate Sodium Salt, Monoclinic Form"
  • 30. Donnelly T. E.Barron B., Biochim. Biophys. Acta, 657, 168 - 178 (1981), "Effects of Divalent Metals on the Specificity of Inhibitors of the Cyclic Nucleotide Phosphodiesterases from Bovine Heart"
  • 31. Murphy B. E.Stone J. E., Biochem. Biophys. Res. Commun., 89, 122 - 128 (1979), "Radioimmunoassay of Cytidine 3´,5´ Monophosphate (cCMP) I. Development of the Assay"
  • 32. Cheng Y.-C.Bloch A., J. Biol. Chem., 253, 2522 - 2524 (1978), "Demonstration, in Leukemia L-1210 Cells, of a Phosphodiesterase Acting on 3':5'-Cyclic CMP but not on 3':5'-Cyclic AMP or 3':5'-Cyclic GMP"
  • 33. Kuo J. F., Brackett N. L., Shoji M.Tse J., J. Biol. Chem., 253, 2518 - 2521 (1978), "Cytidine 3':5'-Monophosphate Phosphodiesterase in Mammalian Tissues - Occurence and Biological Involvement"
  • 34. Bloch A., Adv. Cyclic Nucl. Res., 5, 331 - 338 (1975), "Isolation of Cytidine 3',5'-Monophosphate from Mammalian Tissues and Body Fluids and Its Effects on Leukemia L-1210 Cell Growth in Culture"
  • 35. Bloch A., Biochem. Biophys. Res. Commun., 58, 652 - 659 (1974), "Cytidine 3',5'-Monophosphate (Cyclic CMP) - Isolation from Extracts of Leukemia L-1210 Cells"
  • 36. Bloch A., Dutschman G.Maue R., Biochem. Biophys. Res. Commun., 59, 955 - 959 (1974), "Cytidine 3',5'-Monophosphate (Cyclic CMP) - Initiation of Leukemia L-1210 Cell Growth In Vitro"
  • 37. Nelböck M., Michal G.Weimann G., Pure Appl. Chem., 35, 411 - 437 (1973), "Analogues of Cyclic AMP and their Physiological Response"
  • 38. Long R. A., Szekeres G. L., Khwaja T. A., Sidwell R. W., Simon L. N.Robins R. K., J. Med. Chem., 15, 1215 - 1218 (1972), "Synthesis and Antitumor and Antiviral Activities of 1-ß-D-Arabinofuranosylpyrimidine 3', 5'- Cyclic Phosphates"
  • 39. Blecher M., Ro'Ane J. T.Flynn P. D., Arch. Biochem. Biophys., 142, 351 - 362 (1971), "Biological Roles for 3',5'- Cyclic Nucleotides. I. Lipolytic Agents in isolated Rat Epididymal Adipose Cells and Substrates for Adipose Tissue Phosphodiesterase"
  • 40. Blecher M., Ro'Ane J. T.Flynn P. D., Biochem. Pharmacol., 20, 249 - 251 (1971), "Biochemical Activities of Tubercidin 3', 5'-cyclic Monophosphate in Rat Epididymal Adipose Tissue"
  • 41. Michal G., Nelböck M.Weimann G., Z. Anal. Chem., 252, 189 - 193 (1970), "Cyclophosphate III. Spaltung Verschiedener Cyclophosphate durch Phosphodiesterase aus Herz und Fettgewebe"
  • 42. Levine R. A.Washington A., Endocrinology, 87, 377 - 382 (1970), "Glycogenolytic Activity of Cyclic 3',5'-Monophosphates in Perfused Rat Liver"
  • 43. Drummond G. I.Powell C. A., Mol. Pharmacol., 6, 24 - 30 (1970), "Analogues of Adenosine 3', 5'-Cyclic Phosphate as Activators of Phosphorylase b Kinase and as Substrates for Cyclic 3', 5'-Nucleotide Phosphodiesterase"
  • 44. Kuo J. F., Krueger B. K., Sanes J. R.Greengard P., Biochim. Biophys. Acta, 212, 79 - 91 (1970), "Cyclic Nucleotide-dependent Protein Kinases - V. Preparation and Properties of Adenosine-3', 5'-Monophosphate-dependent Protein Kinase from Various Bovine Tissues"

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