For other salt forms or a guaranteed higher purity please inquire. In pppG(2',5')pA a 5'-GTP unit is connected with a 5'-AMP unit via a 2' → 5' linkage to form a linear dinucleotide. pppG(2',5')pA is considered to be the linear catalytic intermediate in the enzymatic production of 2',3'-cGAMP (aka c[G(2',5')pA(3',5')p], BIOLOG Cat. No. C 161) by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). According to Hall et al. the human stimulator of interferon genes STING155-341 does not bind pppG(2',5')pA at concentrations of up to 50 µM. Reference: Hall et al., Protein Sci., 26, 2367 - 2380 (2017).
Vial containing 100 µl of 10 mM aqueous solution of pH 7.6
Cat. No. | T 051 |
CAS number | [1445905-50-9] |
Purity | > 95% HPLC |
Salt form | Sodium |
Appearance | 10 mM aqueous solution |
Storage temperature | -70°C / -94°F |
Molecular formula | C₂₀H₂₈N₁₀O₂₀P₄ |
Molecular weight [g/mol] | 852.4 |
Absorption max [nm] | 256 |
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 25050 |
UV pH value | 7 |
Solvent for UV data | Water |