The metazoan cyclic dinucleotide second messenger c[G(2',5)pA(3',5')p] (aka
2'3'-cGAMP or cGAMP(2',5'), Cat. No. C 161
) immobilized on agarose by an aminoethylthio spacer attached to position 8 of the guanine nucleobase of the ligand. The gel may be useful for affinity chromatography of c[G(2',5')pA(3',5')p]-responsive proteins. Free c[8-AET-G(2',5')pA(3',5')p] is offered as well (Cat. No. C 175). Detailed technical information available. Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request. Corresponding negative control gel without nucleotide modification: E 010.