The membrane-permeable AICAR activates AMP-activated protein kinase (AMPK) via its phosphorylated metabolite AICAR-5'-MP (Cat. No. A 105). Detailed technical information available. References: Fediuc et al., Endocrinology, 147, 5170 - 5177 (2006); Prasad et al., J. Neurosci. Res., 84, 614 - 625 (2006).