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8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-CPT-cAMP-AM )
Metabolically activatable prodrug form of 8-CPT-cAMP
Cat. No.: C 056
CAS No.: [663941-66-0]
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Cat. No.: C 056-01
Unit: 1 µmol / ~0.5 mg
Membrane-permeant precursor of the PKA activator 8-CPT-cAMP (Cat. No. C 010). Metabolic activation by esterases releases the active analogue. Detailed technical information available. Reference: Kruppa et al., Bioorg. Med. Chem. Lett., 7, 945 - 948 (1997). Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. C 056
CAS number [663941-66-0]
Purity > 97% HPLC for mixture of isomers
Storage temperature -20°C / -4°F
Molecular formula C₁₉H₁₉ClN₅O₈PS
Molecular weight [g/mol] 543.9
Modifications 8-cAMP
Target PKA (cAK) Activator
Absorption max [nm] 282
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000
  • 1. Chepurny O. G., Bertinetti D., Diskar M., Leech C. A., Afshari P., Tsalkova T., Cheng X., Schwede F., Genieser H.-G., Herberg F. W.Holz G. G., Mol. Endocrinol., 27, 1267 - 1282 (2013), "Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag"
  • 2. Kruppa J., Keely S., Schwede F., Schultz C., Barrett K. E.Jastorff B., Bioorg. Med. Chem. Lett., 7, 945 - 948 (1997), "Bioactivatable Derivatives of 8-Substituted cAMP-Analogues"