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Alternative structural projections:


8- (4- Chlorophenylthio)- N6- phenyladenosine- 3', 5'- cyclic monophosphate ( 8-CPT-6-Phe-cAMP ), sodium salt

Potent membrane-permeant PKA agonist
Cat. No.: C 043
CAS No.: [72549-36-1]
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Product Name Price (net) Qty
Cat. No.: C 043-05
Unit: 5 µmol / ~2.8 mg
Highly lipophilic site-selective activator of protein kinase A (cyclic AMP agonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Detailed technical information and updated reference list available. Reference: Miller et al., J. Med. Chem., 23, 242 - 251 (1980).
Cat. No. C 043
CAS number [72549-36-1]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₂₂H₁₈ClN₅O₆PS·Na
Molecular weight [g/mol] 569.9
Modifications 8-cAMP
Target PKA (cAK) Activator
Lipophilicity 3.69
Absorption max [nm] 309
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 25000
  • 1. Christensen A. E., Selheim F., de Rooij J., Dremier S., Schwede F., Dao K. K., Martinez A., Maenhaut C., Bos J. L., Genieser H.-G.Doeskeland S. O., J. Biol. Chem., 278, 35394 - 35402 (2003), "cAMP Analog Mapping of Epac1 and cAMP-Kinase. Discriminating Analogs Demonstrate that Epac and cAMP-Kinase Act Synergistically to Promote PC-12 Cell Neurite Extension"
  • 2. Miller J. P., Boswell K. H., Meyer R. B., Christensen L. F.Robins R. K., J. Med. Chem., 23, 242 - 251 (1980), "Synthesis and Enzymatic and Inotropic Activity of Some New 8-Substituted and 6,8-Disubstituted Derivatives of Adenosine Cyclic 3',5- Monophosphate"