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8- Bromoadenosine- 5'- O- diphosphoribose ( 8-Br-ADPR ), sodium salt
Antagonist of ADP-ribose
Cat. No.: B 051
CAS No.: [59259-77-7]
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Product Name Price (net) Qty
Cat. No.: B 051-05
Unit: 5 µmol / ~3.2 mg
For other salt forms or higher purity please inquire. Antagonist of the second messenger ADP-ribose (ADPR), inhibiting ADPR-activated cation transport through TRPM2. Detailed technical information available. Reference: Partida-Sanchez et al., J. Immunol., 179, 7827 - 7839 (2007).
Cat. No. B 051
CAS number [59259-77-7]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₅H₂₂BrN₅O₁₄P₂ (free acid)
Molecular weight [g/mol] 638.2 (free acid)
Absorption max [nm] 265
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Magnone M., Bauer I., Poggi A., Mannino E., Sturla L., Brini M., Zocci E., De Flora A., Nencioni A.Bruzzone S., J.Biol.Chem., 15, 21067 - 21081 (2012), "NAD+ Levels Control Ca2+ Store Replenishment and Mitogen-induced Increase of cytosolic Ca2+ by cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human TLymphocytes"
  • 2. Lange I., Yamamoto S., Partida-Sanchez S., Mori Y., Fleig A.Penner R., Sci. Signal., 2, 0 - 0 (2009), "TRPM2 Functions as a Lysosomal Ca2+-Release Channel in Beta Cells"
  • 3. Partida-Sanchez S., Gasser A., Fliegert R., Siebrands C. C., Dammermann W., Shi G., Mousseau B. J., Sumoza-Toledo A., Bhagat H., Walseth T. F., Guse A. H.Lund F. E., J. Immunol., 179, 7827 - 7839 (2007), "Chemotaxis of Mouse Bone Marrow Neutrophils and Dendritic Cells is Controlled by ADP-Ribose, the Major Product Generated by the CD38 Enzyme Reaction"
  • 4. Siebrands C. C., Dammermann W., Fliegert R., Partida-Sanchez S., Walseth T. F., Lund F. E.Guse A. H., Proceedings of the Fall Meeting, German Society for Biochemistry and Molecular Biology (GBM), Hamburg, Germany, September 16-19, 0, 0 - 0 (2007), "8Br-ADPR: A Novel Antagonist of TRPM2 Channels"
  • 5. Rah S.-Y., Kwak J.-Y.Kim U.-H., Scientific Reports, 0, 0 - 0 (0), "ADP-Ribose/TRM2-mediated Ca2+ Signaling is Essential for Cytolytic Degranulation and Antitumor Activity of Natural Killer Cells"