The second messenger cyclic AMP immobilized on agarose by an aminohexylamino spacer attached to position 8 of the ligand. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. This ligand is also offered with a shorter spacer (8-AEA-cAMP-Agarose
, Cat. No. A 020) and as PDE-resistant version (Sp-8-AHA-cAMPS-Agarose
, Cat. No. A 013). Detailed technical information available. References: Dills et al., Biochemistry
, 3724 - 3731 (1976); Margarucci et al., Mol. BioSyst
, 2311 - 2319 (2011). Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.