The second messenger cyclic AMP immobilized on agarose by an aminohexylamino spacer attached to position 8 of the ligand. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. This ligand is also offered with a shorter spacer
(8-AEA-cAMP-Agarose, Cat. No. A 020) and as PDE-resistant version (
Sp-8-AHA-cAMPS-Agarose, Cat. No. A 013). Detailed technical information available. References: Dills et al.,
Biochemistry,
15, 3724 - 3731 (1976); Margarucci et al.,
Mol. BioSyst.
7, 2311 - 2319 (2011).
Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.