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7-CN-7-C-Ino

7- Cyano- 7- deazainosine ( 7-CN-7-C-Ino / Jaspamycin )

Activator of cAMP-independent protein kinase A of Trypanosoma
Cat. No.: C 214
    
CAS No.: [22242-96-2]
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Cat. No.: C 214-05
Unit: 5 µmol / ~1.5 mg
$141.00

7-CN-7-C-Ino is a potent and highly specific activator of the cAMP-independent trypanosomal protein kinase A (in Trypanosoma brucei EC50 6.5 ± 4.6 nM on the purified holoenzyme, KD 8 ± 2 nM to the regulatory subunit PKAR) that has low toxicity in vivo (Bachmaier et al., Nat. Commun., 10(1):1421 (2019)). It was also described as a naturally occuring metabolite, called Jaspamycin, isolated from the marine sponge Jaspis splendens (Wang et al., J. Nat. Prod., 79, 353 - 361 (2016)).

Cat. No. C 214
CAS number [22242-96-2]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₂H₁₂N₄O₅
Molecular weight [g/mol] 292.3
Target PKA (cAK) Activator
Absorption max [nm] 275
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 10800
UV pH value 11