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Potent inhibitor of adenosine kinase and other protein kinases. Detailed technical information available. References: Flückiger-Isler, et al., Biochem. J., 292, 85 - 91 (1993); Parkinson & Geiger, J. Pharmacol. Exp. Ther., 277, 1397 - 1401 (1996). This compound is also part of the Ko-Libri compound library (K 001)
Cat. No.
I 004
CAS number
[24386-93-4]
Purity
> 98% HPLC
Storage temperature
-20°C / -4°F
Molecular formula
C₁₁H₁₃IN₄O₄
Molecular weight [g/mol]
392.2
Absorption max [nm]
283
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]
8500
1. Zhang X., Jia D., Liu H., Zhu W., Zhang J., Feng J., Yin J., Hao B., Cui D., Deng Y., Xie D., He L.Li B., PLoS ONE, 8, 0 - 0 (2013), "Identification of 5-Iodotubercidin as a Genotoxic Drug with Anti-Cancer Potential"
2. Long M. C.Parker W. B., Biochem. Pharmacol., 71, 1671 - 1682 (2006), "Structure-activity Relationship for Nucleoside Analogs as Inhibitors or Substrates of Adenosine Kinase from Mycobacterium Tuberculosis I. Modifications to the Adenine Moiety"
3. Kozlowska M., Smolenski R. T., Makarewicz W., Hoffmann C., Jastorff B.Swierczynski J., Toxicol. Lett., 104, 171 - 181 (1999), "ATP Depletion, Purine Riboside Triphosphate Accumulation and Rat Thymocyte Death Induced by Purine Riboside"
4. Parkinson F. E.Geiger J. D., J. Pharmacol. Exp. Ther., 277, 1397 - 1401 (1996), "Effects of Iodotubercidin on Adenosine Kinase Activity and Nucleoside Transport in DDT1 MF-2 Smooth Muscle Cells"
5. Massillon D., Stalmans W., Van de Werve G.Bollen M., Biochem. J., 299, 123 - 128 (1994), "Identification of the Glycogenic Compound 5-iodotubercidin as a General Protein Kinase Inhibitor"
6. Flückiger-Isler R. E.Walter P., Biochem. J., 292, 85 - 91 (1993), "Stimulation of Rat Liver Glycogen Synthesis by the Adenosine Kinase Inhibitor 5-Iodotubercidin"
7. Bergstrom D. E., Brattesani A. J., Ogawa M. K., Reddy P. A., Schweickert M. J., Balzarini J.De Clercq E., J. Med. Chem., 27, 285 - 292 (1984), "Antiviral Activity of C-5 Substituted Tubercidin Analogs"