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2'-O-Bn-3'-MANT-GTP

2'- O- Benzyl- 3'- O- (N'- methylanthraniloyl)guanosine- 5'- O- triphosphate ( 2'-O-Bn-3'-MANT-GTP ), sodium salt

Ribose-modified fluorescent GTP analogue
Cat. No.: B 187
    
CAS No.: [pending]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: B 187-01
Unit: 1 µmol / ~0.7 mg
$165.00

For other salt forms or a guaranteed higher purity please inquire. 2'-O-Bn-3'-MANT-GTP is a fluorescent (λexc 350 nm; λem 442 nm) analogue of GTP where the ribose hydroxy groups have been modified by an ether bond to a benzyl group and an ester bond to a fluorescent MANT group, respectively. Significantly improved stability against esterases compared to other 2'/3'-esters of the ribose like MANT-GTP (Cat. No. M 032). Potential inhibitor of various adenylyl cyclase isoforms and soluble guanylyl cyclase (sGC). References for related GTP analogs and nucleoside triphosphate analogs: Dove et al., Mol. Pharmacol.85, 598 - 607 (2014), Geduhn et al., J. Pharmacol. Exp. Ther., 336, 104 - 115 (2011)

 

Vial containing 1 ml of 1 mM aqueous solution of pH 7.6.

Cat. No. B 187
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Appearance 1 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Light-sensitive True
Molecular formula C₂₅H₂₉N₆O₁₅P₃ (free acid)
Molecular weight [g/mol] 746.5 (free acid)
Excitation max [nm] 350
Emission max [nm] 442
Absorption max [nm] 355
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 5800
UV pH value 7
Solvent for UV data Water