Alternative structural projections:
The second messenger cyclic GMP immobilized on agarose by an aminohexyl spacer attached to the 2-amino group of the ligand. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Detailed technical information available. References: Kim & Park, J. Biochem. Mol. Biol., 36, 299 - 304 (2003); Margarucci et al., Mol. BioSyst., 7, 2311 - 2319 (2011). Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.
| Cat. No. | A 056 |
| CAS number | [pending] |
| Storage temperature | 4°C / 39°F |
| Modifications | 2-cGMP |
- 1. Donaldson L.Meier S., Methods Mol. Biol., 1016, 155 - 173 (2013), "An Affinity Pull-Down Approach to Identify the Plant Cyclic Nucleotide Interactome"
- 2. Margarucci L., Roest M., Preisinger C., Bleijerveld O. B., van Holten T. C., Heck A. J. R.Scholten A., Mol. Biosyst., 7, 2311 - 2319 (2011), "Collagen Stimulation of Platelets Induces a Rapid Spatial Response of cAMP and cGMP Signaling Scaffolds"
- 3. Scholten A., Poh M. K., Vandekerckhove J., van Breukelen B., Vos M. A.Heck A. J. R., J. Proteome Res., 5, 1435 - 1447 (2006), "Analysis of the cGMP/cAMP Interactome Using a Chemical Proteomics Approach in Mammalian Heart Tissue Validates Sphingosine Kinase Type 1-interacting Protein as a Genuine and Highly Abundant AKAP"
- 4. Kim E.Park J. M., J. Biochem. Mol. Biol., 36, 299 - 304 (2003), "Identification of Novel Target Proteins of Cyclic GMP Signaling Pathways Using Chemical Proteomics"
