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2'- , 2''- O- (Di- methyl)- cyclic diguanosine monophosphate ( 2',2''-Di-O-Me-c-diGMP ), sodium salt
Cat. No.: D 136
CAS No.: [849214-02-4]
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Product Name Price (net) Qty
Cat. No.: D 136-001
Unit: 0.1 µmol / ~72 µg

For other salt forms please inquire. 2',2''-Di-O-Me-c-diGMP is an analogue of the bacterial second messenger c-diGMP (Cat. No. C 057) which selectively binds the c-diGMP class II riboswitch over the class I riboswitch. It can be useful for discriminating between these two classes of c-diGMP-binding RNAs and for studying RNA-based c-diGMP signalling. Detailed technical information available. References: Smith et al., Proc. Nat. Acad. Sci. USA, 108, 7757 - 7762 (2011), Launer-Felty et al., Nucleic Acid Res., 46, 2765 - 2776 (2018).

Cat. No. D 136
CAS number [849214-02-4]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₂H₂₈N₁₀O₁₄P₂ (free acid)
Molecular weight [g/mol] 718.5 (free acid)
Absorption max [nm] 253
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 23700
  • 1. Shanahan C. A., Gaffney B. L., Jones R. A.Strobel S. A., Biochemistry, 52, 365 - 377 (2013), "Identification of c-di-GMP Derivatives Resistant to an EAL Domain Phosphodiesterase"
  • 2. Zhou J., Watt S., Wang J., Nakayama S., Sayre D. A., Lam Y.-F., Lee V. T.Sintim H. O., Bioorg. Med. Chem.,, 21, 4396 - 4404 (2013), "Potent Suppression of c-diGMP Synthesis Via I-Site Allosteric Inhibition of Diguanylate Cyclases with 2'-F-c-diGMP"
  • 3. Smith K. D., Shanahan C. A., Moore E. L., Simon A. C.Strobel S. A., Proc. Natl. Acad. Sci. USA, 108, 7757 - 7762 (2011), "Structural Basis of Differential Ligand Recognition by Two Classes of bis-(3'-5')-cyclic Dimeric Guanosine Monophosphate-binding Riboswitches"