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Collaborative Papers and Posters co-authored by BIOLOG Scientists

119 Schwede, F.; Bertinetti, D.; Langerijs, C.N.; Hadders, M.A.; Wienk, H.; Ellenbroek, J.H.; de Koning, E.J.P.; Bos, J.L.; Herberg, F.W.; Genieser, H.-G.; Janssen, R.A.; Rehmann, H., PLoS Biol., 13, 1 - 26 (2015): "Structure-Guided Design of Selective Epac1 and Epac2 Agonists"
118 Villano, D.; Vilaplana, C.; Medina, S.; Cejuela-Anta, R.; Martínez-Sanz, J.M.; Gil, P.; Genieser, H.-G.; Ferreres, F.; Gil-Izquierdo, A., Free Radical Research, 49, 973 - 983 (2015): "Effect of Elite Physical Exercises by Triathletes on Seven Catabolites of DNA Oxidation"
117 Lolicato, M.; Bucchi, A.; Arrigoni, C.; Zucca, S.; Nardini, M.; Schroeder, I.; Simmons, K.; Aquila, M.; DiFrancesco, D.; Bolognesi, M.; Schwede, F.; Kashin, D.; Fishwick, C.W.G.; Johnson, A.P.; Thiel, G.; Moroni, A., Nat. Chem. Biol., 10, 457 - 462 (2014): "Cyclic Dinucleotides bind the C-linker of HCN4 to Control Channel cAMP Responsiveness"
116 Beckert, U.; Grundmann, M.; Wolter, S.; Schwede, F.; Rehmann, H.; Kaever, V.; Kostenis, E.; Seifert, R., Biochem. Biophys. Res. Commun., 451, 497 - 502 (2014): "cNMP-AMs Mimic and Dissect Bacterial Nucleotidyl Cyclase Toxin Effects"
115 Wolter, S.; Dove, S.; Golombek, M.; Schwede, F.; Seifert, R., Naunyn-Schmiedeberg's Arch. Pharmacol., 387, 1163 - 1175 (2014): "N4-monobutyryl-cCMP Activates PKA RIalpha and PKA RIIalpha more Potently and with Higher Efficacy than PKG Ialpha in Vitro but not in Vivo"
114 Almahariq, M.; Tsalkova, T.; Mei, F.C.; Chen, H.; Zhou, J.; Sastry, S.K.; Schwede, F.; Cheng, X., Mol. Pharmacol., 83, 122 - 128 (2013): "A Novel EPAC Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion"
113 Gausdal, G.; Wergeland, A.; Skavland, J.; Nguyen, E.; Pendino, F.; Rouhee, N.; McCormack, E.; Herfindal, L.; Kleppe, R.; Havemann, U.; Schwede, F.; Bruseud, O.; Gjertsen, B.T.; Lanotte, M.; Segal-Bendirdjian, E.; Doskeland, S.O., Cell Death Dis., 4 (2013): "Cyclic AMP Can Promote APL Progression and Protect Myeloid Leukemia Cells Against Anthracycline-Induced Apoptosis"
112 Chepurny, O.G.; Bertinetti, D.; Diskar, M.; Leech, C.A.; Afshari, P.; Tsalkova, T.; Cheng, X.; Schwede, F.; Genieser, H.-G.; Herberg, F.W.; Holz, G.G., Mol. Endocrinol., 27, 1267 - 1282 (2013): "Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag"
111 Düvel, J.; Bertinetti, D.; Möller, S.; Schwede, F.; Morr, M.; Wissing, J.; Radamm, L.; Zimmermann, B.; Genieser, H.-G.; Jänsch, L.; Herberg, F.W.; Häussler, S., J. Microbiol. Methods., 88, 229 - 236 (2012): "A Chemical Proteomics Approach to Identify c-di-GMP Binding Proteins in Pseudomonas Aeruginosa"
110 Kusch, J.; Thon, S.; Schulz, E.; Biskup, C.; Nache, V.; Zimmer, T.; Seifert, R.; Schwede, F.; Benndorf, K., Nat. Chem. Biol., 8, 162 - 169 (2012): "How Subunits Cooperate in cAMP-induced Activation of Homotetrameric HCN2 Channels"
109 Jäger, R.; Russwurm, C.; Schwede, F.; Genieser, H.-G.; Koesling, D.; Russwurm, M., J. Biol. Chem., 287, 1210 - 1219 (2012): "Activation of PDE10 and PDE11 Phosphodiesterases"
108 Hammerschmidt, A.; Chatterji, B.; Zeiser, J.; Schröder, A.; Genieser, H.-G.; Pich, A.; Kaever, V.; Schwede, F.; Wolter, S.; Seifert, R., PLoS ONE, 7, 39848 (2012): "Binding of Regulatory Subunits of cyclic AMP-dependent Protein Kinase to cyclic CMP Agarose"
107 Nache, V.; Zimmer, T.; Wongsamitkul, N.; Schmauder, R.; Kusch, J.; Reinhardt, L.; Bönigk, W.; Seifert, R.; Biskup, C.; Schwede, F.; Benndorf, K., Sci. Signal., 5 (2012): "Differential Regulation by Cyclic Nucleotides of the CNGA4 and CNGB1b Subunits in Olfactory Cyclic Nucleotide-Gated Channels"
106 Huseby, S.; Gausdal, G.; Keen, T.J.; Kjærland, E.; Krakstad, C.; Myhren, L.; Brønstad, K.; Kunick, C.; Schwede, F.; Genieser, H.-G.; Kleppe, R.; Doeskeland, S.O., Cell Death Dis., e237, 2 (2011): "Cyclic AMP Induces IPC Leukemia Cell Apoptosis via CRE-and CDK-dependent Bim Transcription"
105 Börner, S.; Schwede, F.; Schlipp, A.; Berisha, F.; Calebiro, D.; Lohse, M.J.; Nikolaev, V.O., Nat. Protoc., 6, 427 - 438 (2011): "FRET Measurements of Intracellular cAMP Concentrations and cAMP Analog Permeability in Intact Cells"
104 Hanke, S.E.; Bertinetti, D.; Badel, A.; Schweinsberg, S.; Genieser, H.-G.; Herberg, F.W., N. Biotechnol., 28, 294 - 301 (2011): "Cyclic Nucleotides as Affinity Tools: Phosphorothioate cAMP Analogues Adress Specific PKA Subproteomes"
103 Dzhura, I.; Chepurny, O.G.; Leech, C.A.; Roe, M.W.; Dzhura, E.; Xu, X.; Lu, Y.; Schwede, F.; Genieser, H.-G.; Smrcka, A.V.; Holz, G.G., Islets, 3, 121 - 128 (2011): "Phospholipase C-epsilon Links Epac2 Activation to the Potentiation of Glucose-stimulated Insulin Secretion from Mouse Islets of Langerhans"
102 Werner, K.; Schwede, F.; Genieser, H.-G.; Geiger, J.; Butt, E., Naunyn Schmiedebergs Arch. Pharmacol., 384, 169 - 176 (2011): "Quantification of cAMP and cGMP Analogs in Intact Cells: Pitfalls in Enzyme Immunoassays for Cyclic Nucleotides"
101 Holz, G.G.; Chepurny, O.G.; Leech, C.A.; Dzhura, I.; Kelley, G.G.; Roe, W.R.; Dzhura, E.; Li, X.; Schwede, F.; Genieser, H.-G., Biophys. J., 98, 680 - 680 (2010): "A Permissive Role for Protein Kinase A in Support of Epac Agonist-Stimulated Human Islet Insulin Secretion"
100 Leech, C.A.; Dzhura, I.; Chepurny, O.G.; Schwede, F.; Genieser, H.-G.; Holz, G.G., Islets, 2, 72 - 81 (2010): "Facilitation of beta-cell KATP Channel Sulfonylurea Sensivity by a cAMP Analog Selective for the cAMP-regulated Guanine Nucleotide Exchange Factor Epac"
99 Chepurny, O.G.; Kelley, G.G.; Dzhura, I.; Leech, C.A.; Roe, M.W.; Dzhura, E.; Li, X.; Schwede, F.; Genieser, H.-G.; Holz, G.G., Am. J. Physiol.-Endocrinol. Metabol., 298, 622 - 633 (2010): "PKA-dependent Potentiation of Glucose-stimulated Insulin Secretion by Epac Activator 8-pCPT-2'-O-Me-cAMP-AM in Human Islets of Langerhans"
98 Béres, T.; Zatloukal, M.; Voller, J.; Niemann, P.; Gahsche, M.C.; Tarkowski, P.; Novák, O.; Hanus, J.; Strnad, M.; Dolezal, K., Anal. Bioanal. Chem., 398, 2071 - 2080 (2010): "Tandem Mass Spectrometry Identification and LC-MS Quantification of Intact Cytokinin Nucleotides in K-562 Human Leukemia Cells"
97 Voller, J.; Zatloukal, M.; Lenobel, R.; Dolezal, K.; Béres, T.; Krystof, V.; Spíchal, L.; Niemann, P.; Dzubák, P.; Hajdúch, M.; Strnad, M., Phytochem., 71, 1350 - 1359 (2010): "Anticancer Activity of Natural Cytokinins: A Structure-activity Relationsship Study"
96 Jäger, R.; Schwede, F.; Genieser, H.-G.; Koesling, D.; Russwurm, M., Br. J. Pharmacol., 161, 1645 - 1660 (2010): "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
95 Kusch, J.; Biskup, C.; Thon, S.; Schulz, E.; Nache, V.; Zimmer, T.; Schwede, F.; Benndorf, K., Neuron, 67, 75 - 85 (2010): "Interdependence of Receptor Activation and Ligand Binding in HCN2 Pacemaker Channels"
94 Erikstein, B.S.; McCormack, E.; Tronstad, K.J.; Schwede, F.; Berge, R.; Gjertsen, B.T., Leuk Res., 34, 77 - 84 (2010): "Protein Kinase A Activators and the Pan-PPAR Agonist Tetradecylthioacetic Acid Elicit Synergistic Anti-leukaemic Effects in AML through CREB"
93 Bertinetti, D.; Schweinsberg, S.; Hanke, S.E.; Schwede, F.; Bertinetti, O.; Drewianka, S.; Genieser, H.-G.; Herberg, F.W., BMC Chem Biol, 9 (2009): "Chemical tools selectively target components of the PKA system"
92 Chepurny, O.G.; Leech, C.A.; Kelley, G.G.; Dzhura, I.; Dzhura, E.; Li, X.; Rindler, M.J.; Schwede, F.; Genieser, H.-G.; Holz, G.G., J. Biol. Chem., 284, 10728 - 10736 (2009): "Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: Studies with 8-pCPT-2'-O-Me-cAMP-AM."
91 Kelley, G.G.; Chepurny, O.G.; Schwede, F.; Genieser, H.-G.; Leech, C.A.; Roe, M.W.; Li, X.; Dzhura, I.; Dzhura, E.; Afshari, P.; Holz, G.G., Islets, 1, 260 - 265 (2009): "Glucose-dependent Potentation of Mouse Islet Insulin Secretion by Epac Activator 8-pCPT-2'-O-Me-cAMP-AM"
90 Herfindal, L.; Kasprzykowski, F.; Schwede, F.; Lankiewicz, L.; Fladmark, K.E.; Lukomska, J.; Wahlsten, M.; Sivonen, K.; Grzonka, Z.; Jastorff, B.; Doeskeland, S.O., J. Med. Chem., 52, 5758 - 5762 (2009): "Acyloxymethyl Esterification of Nodularin-R and Microcystin-LA Produces Inactive Protoxins That Become Reactivated and Produce Apoptosis Inside Intact Cells"
89 Poppe, H.; Rybalkin, S.D.; Rehmann, H.; Hinds, T.R.; Tang, X.-B.; Christensen, A.E.; Schwede, F.; Genieser, H.-G.; Bos, J.L.; Doeskeland, S.O.; Beavo, J.A.; Butt, E., Nature Methods, 5, 277 - 278 (2008): "Cyclic Nucleotide Analogs as Probes of Signaling Pathways"
88 Holz, G.G.; Chepurny, O.G.; Schwede, F., Cell. Signal., 20, 10 - 20 (2008): "Epac-selective cAMP Analogs: New Tools with which to Evaluate the Signal Transduction Properties of cAMP-regulated Guanine Nucleotide Exchange Factors"
87 Schweinsberg, S.; Moll, D.; Burghardt, N.C.; Hahnefeld, C.; Schwede, F.; Zimmermann, B.; Drewianka, S.; Werner, L.; Kleinjung, F.; Genieser, H.-G.; Schuchhardt, J.; Herberg, F.W., Proteomics, 8, 1212 - 1220 (2008): "Systematic interpretation of cyclic nucleotide binding studies using KinetXBase"
86 Moll, D.; Prinz, A.; Brendel, C.M.; Berrera, M.; Guske, K.; Zaccolo, M.; Genieser, H.-G.; Herberg, F.W., BMC Biochem., 9, 18 - 18 (2008): "Biochemical Characterization and Cellular Imaging of a Novel, Membrane Permeable Fluorescent cAMP Analog"
85 Vliem, M.J.; Ponsioen, B.; Schwede, F.; Pannekoek, W.-J.; Riedl, J.; Kooistra, M.R.H.; Jalink, K.; Genieser, H.-G.; Bos, J.L.; Rehmann, H., ChemBioChem, 9, 2052 - 2054 (2008): "8-pCPT-2'-O-Me-cAMP-AM: An Improved Epac-selective cAMP Analogue"
84 Rehmann, H.; Arias-Palomo, E.; Hadders, M.A.; Schwede, F.; Llorca, O.; Bos, J.L., Nature, 455, 124 - 127 (2008): "Structure of Epac2 in Complex with a cyclic AMP Analogue and RAP1B"
83 Ouyang, M.; Zhang, L.; Zhu, J.J.; Schwede, F.; Thomas, S.A., PNAS, 105, 11993 - 11997 (2008): "Epac Signaling is Required for Hippocampus-dependent Memory Retrieval"
82 Rodriguez-Collazo, P.; Snyder, S.K.; Chiffer, R.C.; Bressler, E.A.; Voss, T.C.; Anderson, E.P.; Genieser, H.-G.; Smith, C.L., Exp. Cell Res., 314, 2855 - 2869 (2008): "cAMP Signaling Regulates Histone H3 Phosphorylation and Mitotic Entry Through a Disruption of G2 Progression"
81 Biskup, C.; Kusch, J.; Schulz, E.; Nache, V.; Schwede, F.; Lehmann, F.; Hagen, V.; Benndorf, K., Nature, 446, 440 - 443 (2007): "Relating ligand binding to activation gating in CNGA2 channels"
80 Laxman, S.; Riechers, A.; Sadilek, M.; Schwede, F.; Beavo, J.A., PNAS, 103, 19194 - 19199 (2006): "Hydrolysis Products of cAMP Analogs Cause Transformation of Trypanosoma Brucei from Slender to Stumpy-like Forms"
79 Bryn, T.; Mahic, M.; Enserink, J.M.; Schwede, F.; Aandahl, E.M.; Tasken, K., J. Immunol., 176, 7361 - 7370 (2006): "The cyclic AMP-Epac1-Rap1 Pathway is Dissociated from Regulation of Effector Functions in Monocytes but Acquires Immunoregulatory Function in Mature Macrophages"
78 Dao, K.K.; Teigen, K.; Kopperud, R.K.; Hodneland, E.; Schwede, F.; Christensen, A.E.; Martinez, A.; Doeskeland, S.O., J. Biol. Chem., 281, 21500 - 21511 (2006): "Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition"
77 Kang, G.; Chepurny, O.G.; Malester, B.; Rindler, M.J.; Rehmann, H.; Bos, J.L.; Schwede, F.; Coetzee, W.A.; Holz, G.G., J. Physiol.-London, 573, 595 - 609 (2006): "cAMP Sensor Epac as a Determinant of ATP-sensitive Potassium Channel Activity in Human Pancreatic Beta Cells and Rat INS-1 Cells"
76 Makarevich, A.V.; Sirotkin, A.V.; Genieser, H.-G., Anim. Reprod. Sci., 81, 125 - 136 (2004): "Action of Protein Kinase A Regulators on Secretory Activity of Porcine Granulosa Cells in Vitro"
75 Mahic, M.; Bryn, T.; Enserink, J.M.; Schwede, F.; Aandahl, E.M.; Tasken, K., Poster #THP019 Montreal, 12 (2004): "Modulation of Monocyte Activation by Cyclic AMP is Mainly Mediated Through Protein Kinase A"
74 Selheim, F.; Krakstad, C.; Christensen, A.-E.; Hagland, H.; Schwede, F.; Genieser, H.-G.; Doeskeland, S.O., Poster # THP017 Montreal, 12 (2004): "The cAMP Receptor Epac Has a Permissive Role for cAMP-dependent Protein Kinase Action to Protect PC-12 Pheochromocytoma Cells Against Stress-induced Apoptosis and Induce Neuronal Differentiation"
73 Genieser, H.-G.; Bos, J.L.; Christensen, A.E.; Doeskeland, S.O.; Havemann, U.; Manzau, U.; Rehmann, H.; Schwede, F., Poster #THP016 Montreal, 12 (2004): "Analogues of Cyclic AMP to Distinguish Between PKA and Epac"
72 Weissinger, E.M.; Oettrich, K.; Evans, C.; Genieser, H.-G.; Schwede, F.; Dangers, M.; Dammann, E.; Kolb, H.-J.; Mischak, H.; Ganser, A.; Kolch, W., Brit. J. Cancer, 91, 186 - 192 (2004): "Activation of Protein Kinase A (PKA) by 8-Cl-cAMP as a Novel Approach for Antileukaemic Therapy"
71 Kang, G.; Joseph, J.W.; Chepurny, O.G.; Monaco, M.; Wheeler, M.B.; Bos, J.L.; Schwede, F.; Genieser, H.-G.; Holz, G.G., J. Biol. Chem., 278, 8279 - 8285 (2003): "Epac-Selective cAMP Analog 8-pCPT-2'-O-Me-cAMP As A Stimulus For Ca 2+ -Induced Ca 2+ Release And Exocytosis In Pancreatic Beta-Cells"
70 Rangarajan, S.; Enserink, J.M.; Kuiperij, H.B.; de Rooij, J.; Price, L.S.; Schwede, F.; Bos, J.L., J. Cell Biol., 160, 487 - 493 (2003): "Cyclic AMP Induces Integrin-mediated Cell Adhesion Through Epac and Rap1 Upon Stimulation of the ß2-Adrenergic Receptor"
69 Rehmann, H.; Schwede, F.; Doeskeland, S.O.; Wittinghofer, A.; Bos, J.L., J. Biol. Chem., 278, 38548 - 38556 (2003): "Ligand-mediated Activation of the cAMP-responsive Guanine Nucleotide Exchange Factor Epac"
68 Bartsch, M.; Zorn-Kruppa, M.; Kühl, N.; Genieser, H.-G.; Schwede, F.; Jastorff, B., Biol. Chem., 384, 1321 - 1326 (2003): "Bioactivatable, Membrane-permeant Analogs of Cyclic Nucleotides as Biological Tools for Growth Control of C6 Glioma Cells"
67 Christensen, A.E.; Selheim, F.; de Rooij, J.; Dremier, S.; Schwede, F.; Dao, K.K.; Martinez, A.; Maenhaut, C.; Bos, J.L.; Genieser, H.-G.; Doeskeland, S.O., J. Biol. Chem., 278, 35394 - 35402 (2003): "cAMP Analog Mapping of Epac1 and cAMP-Kinase. Discriminating Analogs Demonstrate that Epac and cAMP-Kinase Act Synergistically to Promote PC-12 Cell Neurite Extension"
66 Christensen, A.E.; de Rooij, J.; Kopperud, R.K.; Nilsen, O.K.; Dao, K.K.; Schwede, F.; Bos, J.L.; Genieser, H.-G.; Doeskeland, S.O., Abstract of the 13th Protein Kinase Symposium, 5 - 5 (2002): "Comparison of the cAMP Binding Sites of EPAC-1 and cAMP-Kinase"
65 Enserink, J.M.; Christensen, A.E.; de Rooij, J.; van Triest, M.; Schwede, F.; Genieser, H.-G.; Doeskeland, S.O.; Blank, J.L.; Bos, J.L., Nature Cell Biol., 4, 901 - 906 (2002): "A Novel Epac-specific cAMP Analogue Demonstrates Independent Regulation of Rap 1 and ERK"
64 Sirotkin, A.V.; Makarevich, A.V.; Pivko, J.; Genieser, H.-G., Asian Austral. J. Anim. Sci., 15, 1045 - 1050 (2002): "Intracellular Mechanisms of Growth Hormone Action on Apoptosis in Cultured Porcine Ovarian Granulosa Cells"
63 Sirotkin, A.V.; Makarevich, A.V.; Kwon, H.B.; Kotwica, J.; Genieser, H.-G.; Pivko, J., Endocrine Abstracts, 4, 79 (2002): "Effect of Growth Hormone on Porcine Ovarian Cells and its Intracellular Mechanisms"
62 Maronde, E.; Korf, H.W.; Niemann, P.; Genieser, H.-G., J. Pineal Res., 31, 183 - 185 (2001): "Direct Comparison of the Potency of Three Novel cAMP Analogs to Induce CREB-Phosphorylation in Rat Pinealocytes"
61 Wätjen, W.; Benters, J.; Haase, H.; Schwede, F.; Jastorff, B.; Beyersmann, D., Toxicol., 157, 167 - 175 (2001): "Zn2+ and Cd2+ Increase the cyclic GMP level in PC12 Cells by Inhibition of the cyclic Nucleotide Phosphodiesterase"
60 Schwede, F.; Christensen, A.; Liauw, S.; Hippe, T.; Kopperud, R.K.; Jastorff, B.; Doeskeland, S.O., Biochemistry, 39, 8803 - 8812 (2000): "8-Substituted cAMP Analogues Reveal Marked Differences in Adaptability, Hydrogen Bonding, and Charge Accomodation between Homologous Binding Sites (AI/AII and BI/BII) in cAMP Kinase I and II"
59 Sirotkin, A.V.; Mertin, D.; Süvegova, K.; Makarevich, A.V.; Genieser, H.-G.; Luck, M.R.; Osadchuk, L.V., Gen. Comp. Endocrinol., 117, 207 - 217 (2000): "Effect of Restricted Food Intake on Production, Catabolism, and Effects of IGF-I and Cyclic Nucleotides in Cultured Ovarian Tissue of Domestic Nutria (Myocastor coypus)"
58 Schwede, F.; Brustugun, O.T.; Zorn-Kruppa, M.; Doeskeland, S.O.; Jastorff, B., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000): "Membrane-permeant, Bioactivatable Analogues of cGMP as Inducers of Cell Death in IPC-81 Leukemia Cells"
57 Sirotkin, A.V.; Makarevich, A.V.; Genieser, H.-G.; Kotwica, J.; Hetenyi, L., Exp. Clin. Endocrinol. Diabetes, 108, 214 - 219 (2000): "Effect of four cGMP Analogues with Different Mechanisms of Action on Hormone Release by Porcine Ovarian Granulosa Cells In Vitro"
56 Christensen, A.; Dao, K.K.; Doeskeland, S.O.; Schwede, F.; Jastorff, B.; Genieser, H.-G.; de Rooij, J.; Bos, J.L.; Rehmann, H.; Kraemer, A.; Wittinghofer, A., 12th Protein Kinase Symp. "NO/cGMP and Protein Kinase Signaling" Bad Brückenau/Germany (2000): "8-Modified cAMP Analogs give Insight into the Geometries of the cAMP Binding Sites of RI, RII and EPAC-1"
55 Schwede, F.; Maronde, E.; Genieser, H.-G.; Jastorff, B., Pharmacol. Ther., 87, 199 - 226 (2000): "Cyclic Nucleotide Analogs as Biochemical Tools and Prospective Drugs"
54 Sirotkin, A.V.; Makarevich, A.V.; Pivko, J.; Kotwica, J.; Genieser, H.-G.; Bulla, J., J. Steroid Biochem. Mol. Biol., 74, 1 - 9 (2000): "Effect of cGMP Analogues and Protein Kinase G Blocker on Secretory Activity, Apoptosis and the cAMP/Protein Kinase A System in Porcine Ovarian Granulosa Cells In Vitro"
53 Sirotkin, A.V.; Mertin, D.; Süvegova, K.; Makarevich, A.V.; Genieser, H.-G.; Osadchuk, L.V., Animal Production Review (2000): "The Cyclic Nucleotide-IGF-I System as Possible Mediator of Effect of Nutrition on Ovarian Activity in Domestic Nutria (Myocastor coypus)"
52 Sirotkin, A.V.; Mertin, D.; Süvegova, K.; Makarevich, A.V.; Genieser, H.-G.; Luck, M.R.; Osadchuk, L.V., Scientifur, 24, 211 - 211 (2000): "Effect of Restricted Food Intake on Production, Catabolism, and Effects of IGF-I and Cyclic Nucleotides in Cultured Ovarian Tissue of Domestic Nutria (Myocastor coypus)"
51 Maronde, E.; Wicht, H.; Tasken, K.; Genieser, H.-G.; Dehghani, F.; Olcese, J.; Korf, H.-W., J. Pineal Res., 27, 170 - 182 (1999): "CREB Phosphorylation and Melatonin Biosynthesis in the Rat Pineal Gland: Involvement of cyclic AMP-dependent Protein KinaseType II"
50 Sirotkin, A.; Makarevic, A.; Kotwica, J.; Genieser, H.-G.; Bulla, J., J. Farm. Animal. Sci., 32, 11 - 14 (1999): "Effect of Chemical Analogues of cAMP and cGMP on Hormone and Growth Factor Secretion by Porcine Ovarian Cells"
49 Mertin, D.; Sirotkin, A.V.; Süvegova, K.; Makarevich, A.V.; Genieser, H.-G.; Luck, M.R.; Osadchuk, L.V., Society for the Study of Fertility Aberystwyth, 32 (1999): "The Cyclic Nucleotide - IGF-I System as a Possible Link Between Nutrion and Reproduction in Domestic Nutria"
48 Schwede, F.; Genieser, H.-G.; Jastorff, B., Cell. Mol. Biol. Lett., 4, 466 (1999): "Cyclic Nucleotide Analogs as Prospective Drugs"
47 Sirotkin, A.; Makarevich, A.; Chribikova, J.; Genieser, H.-G.; Taradajnik, T.; Marnet, P.-G.; Chrenek, P.; Schaeffer, H.-J.; Mlyncek, M.; Kubek, A.; Bulla, J., Journal for Agricultural Sciences, 43, 391 - 398 (1999): "Secretion and Effects of Growth Factors in Farm Animal and Human Ovaries"
46 Cho-Chung, Y.S.; Jastorff, B.; Genieser, H.-G., USA patent 5916, 843 (1998): "Cyclic AMP Analogues, Individually and in Pairs, to Inhibit Neoplastic Cell Growth"
45 Wei, J.-Y.; Cohen, E.D.; Genieser, H.-G.; Barnstable, C.J., J. Mol. Neurosci., 10, 53 - 64 (1998): "Substituted cGMP Analogs Can Act as Selective Agonists of the Rod Photoreceptor cGMP-Gated Cation Channel"
44 Hebert, M.C.; Schwede, F.; Jastorff, B.; Cote, R.H., J. Biol. Chem., 273, 5557 - 5565 (1998): "Structural Features of the Noncatalytic cGMP Binding Sites of Frog Photoreceptor Phoshodiesterase Using cGMP Analogs"
43 Walton, T.J.; Bayliss, M.A.; Pereira, M.L.; Games, D.E.; Genieser, H.-G.; Brenton, A.G.; Harris, F.M.; Newton, R.P., Rapid Commun. Mass Spectrom., 12, 449 - 455 (1998): "Fast-atom Bombardment Tandem Mass Spectrometry of Cyclic Nucleotide Analogues Used as Site-selective Activators of Cyclic Nucleotide-dependent Protein Kinases"
42 Vaandrager, A.B.; Edixhoven, M.; Bot, A.G.M.; Kroos, M.A.; Jarchau, T.; Lohmann, S.M.; Genieser, H.-G.; De Jonge, H.R., J. Biol. Chem., 272, 11816 - 11823 (1997): "Endogenous Type II cGMP-Dependent Protein Kinase Exists as a Dimer in Membranes and can be Functionally Distinguished from the Type I Isoforms"
41 Krass, J.D.; Jastorff, B.; Genieser, H.-G., Anal. Chem., 69, 2575 - 2581 (1997): "Determination of Lipophilicity by Gradient Elution High-Performance Liquid Chromatography"
40 Kruppa, J.; Keely, S.; Schwede, F.; Schultz, C.; Barrett, K.E.; Jastorff, B., Bioorg. Med. Chem. Lett., 7, 945 - 948 (1997): "Bioactivatable Derivatives of 8-Substituted cAMP-Analogues"
39 Genieser, H.-G.; Walter, U.; Butt, E., US Patent 5625056 of April 29 (1997): "Derivatives of Cyclic Guanosine-3',5'-Monophosphorothioate"
38 Sirotkin, A.V.; Makarevic, A.V.; Genieser, H.-G., 3rd Intl. Conf. Cyclic Nucleotide Phosphodiesterases ( From Genes to Therapies ) Scotland (1996): "The Effect of PDE Inhibitors and Other Regulators of PKA on the Secretory Activity of Porcine Ovarian Granulosa Cells"
37 Kroner, C.; Boekhoff, I.; Lohmann, S.M.; Genieser, H.-G.; Breer, H., Eur. J. Biochem., 236, 632 - 637 (1996): "Regulation of Olfactory Signalling Via cGMP-dependent Protein Kinase"
36 Wei, J.Y.; Cohen, E.D.; Yan, Y.-Y.; Genieser, H.-G.; Barnstable, C.J., Biochemistry, 35, 16815 - 16823 (1996): "Identification of Competitive Antagonists of the Rod Photoreceptor cGMP-Gated Cation Channel: Beta-Phenyl-1,N(2)-Etheno-Substituted cGMP Analogues as Probes of the cGMP-Binding Site"
35 Wei, J.Y.; Cohen, E.D.; Yan, Y.-Y.; Genieser, H.-G.; Barnstable, C.J., American Society for Neuroscience, 880 (1996): "PET-substituted cGMP Analogs: Novel Antagonists of Rod Photoreceptor cGMP-gated Channel"
34 Schwede, F., Ph.D. Thesis (1996): "Synthese und Eigenschaften ausgewählter Analoga von cGMP und ihr Einsatz in der biologischen Forschung"
33 Sirotkin, A.V.; Makarevich, A.V.; Genieser, H.-G., J. Physiol. Pharmacol., 47, 134 (1996): "Effect of Regulators of Protein Kinase A on IGF-I and Steroid Secretion by Porcine Granulosa Cells in Vitro"
32 Hoffmann, C.; Genieser, H.-G.; Veron, M.; Jastorff, B., Bioorg. Med. Chem. Lett., 6, 2571 - 2574 (1996): "Novel Synthesis of Nucleoside 5'-Polyphosphates"
31 Gjertsen, B.T.; Mellgren, G.; Otten, A.; Maronde, E.; Genieser, H.-G.; Jastorff, B.; Vintermyr, O.K.; McKnight, G.S.; Doeskeland, S.O., J. Biol. Chem., 270, 20599 - 20607 (1995): "Novel (Rp)-cAMPS Analogs as Tools for Inhibition of cAMP-Kinase in Cell Culture"
30 Ruchaud, S.; Zorn, M.; Davilar-Villar, E.; Genieser, H.-G.; Hoffmann, C.; Gjertsen, B.T.; Doeskeland, S.O.; Jastorff, B.; Lanotte, M., Cell. Pharmacol., 2, 127 - 140 (1995): "Evidence for Several Pathways of Biological Response to Hydrolysable cAMP-Analogues Using a Model System of Apoptosis in IPC-81 Leukaemia Cells"
29 Gjertsen, B.T.; Mellgren, G.; Vintermyr, O.K.; Genieser, H.-G.; Jastorff, B.; Doeskeland, S.O., Int. Conference on Second Messenger & Phosphoproteins TN USA (1995): "The Basal cAMP-Dependent Protein Kinase (cAK) Activity in Resting Hepatocytes Can Be inhibited By Rp-8-Br-cAMPS, and Has a Permissive Role For IL-1ß Action"
28 Butt, E.; Pöhler, D.; Genieser, H.-G.; Huggins, J.P.; Bucher, B., Br. J. Pharmacol., 116, 3110 - 3116 (1995): "Inhibition of Cyclic GMP-dependent Protein Kinase-mediated Effects by (Rp)-8-bromo-PET- cyclic GMPS"
27 Genieser, H.-G., Proc. 9. Int. Conf. Second Mess. & Phosphoprot. TN USA (1995): "Lipophilic Ranking of Biologically Important Cyclic Nucleotides"
26 Genieser, H.-G.; Bucher, B.; Butt, E., 9th International Conference on Second Messenger & Phosphoproteins (1995): "Rp-8-Br-PET-cGMPS, A New Potent Inhibitor of Cyclic GMP-dependent Protein Kinase"
25 Ruchaud, S.; Duprez, E.; Gendron, M.-C.; Houge, G.; Genieser, H.-G.; Jastorff, B.; Doeskeland, S.O.; Lanotte, M., Proc. Natl. Acad. Sci. USA, 91, 8428 - 8432 (1994): "Two Distinctly Regulated Events, Priming and Triggering, During Retinoid-induced Maturation and Resistance of NB4 Promyelocytic Leukemia Cell Line"
24 Butt, E.; Eigenthaler, M.; Genieser, H.-G., Eur. J. Pharmacol., 269, 265 - 268 (1994): "(Rp)-8-pCPT-cGMPS, a Novel cGMP-dependent Protein Kinase Inhibitor"
23 Schultz, C.; Vajanaphanich, M.; Genieser, H.-G.; Jastorff, B.; Barrett, K.E.; Tsien, R.Y., Mol. Pharmacol., 46, 702 - 708 (1994): "Membrane-permeant Derivatives of Cyclic AMP Optimized for High Potency, Prolonged Activity, or Rapid Reversibility"
22 Oegreid, D.; Dostmann, W.; Genieser, H.-G.; Niemann, P.; Doeskeland, S.O.; Jastorff, B., Eur. J. Biochem., 221, 1089 - 1094 (1994): "(Rp)- and (Sp)- 8- Piperidinoadenosine- 3', 5'- (cyclic) Thiophosphates Discriminate Completely Between Site A and B of the Regulatory Subunits of cAMP-dependent Protein Kinase Type I and II"
21 Sollid, S.; Dostmann, W.R.G.; Genieser, H.-G.; Oegreid, D., Manuskript - Centre of Molecular Medicine Norway, 21 (1994): "(Rp)-Configurated Phophorothioate Analogs of cAMP are both Agonists and Antagonists of cAMP Action"
20 Musgrave, I.F.; Genieser, H.-G.; Maronde, E.; Seifert, R., FEBS Lett., 318, 227 - 230 (1993): "Preparations of Rp- cyclic Adenosine 3', 5'- phosphorothioate (Rp-cAMPS) Can Contain Biologically Active Amounts of Adenosine"
19 Schaap, P.; Van Ments-Cohen, M.; Soede, R.D.M.; Brandt, R.; Firtel, R.A.; Dostmann, W.; Genieser, H.-G.; Jastorff, B.; Van Haastert, P.J.M., J. Biol. Chem., 268, 6323 - 6331 (1993): "Cell-permeable Non-hydrolyzable cAMP Derivatives as Tools for Analysis of Signaling Pathways Controlling Gene Regulation in Dictyostelium"
18 Jastorff, B.; Genieser, H.-G.; Cho-Chung, Y.S., Patent WO9321929 of November 11 (1993): "Phosphorothioate Derivatives of Cyclic AMP Analogues"
17 Naß, N.; Colling, C.; Cramer, M.; Genieser, H.-G.; Butt, E.; Winkler, E.; Jaenicke, L.; Jastorff, B., Biochem. J., 285, 129 - 136 (1992): "Mapping of the Epitope/Paratope Interactions of a Monoclonal Antibody Directed Against Adenosine- 3', 5'- monophosphate"
16 Yokozaki, H.; Tortora, G.; Pepe, S.; Maronde, E.; Genieser, H.-G.; Jastorff, B.; Cho- Chung, Y.S., Cancer Res., 52, 2504 - 2508 (1992): "Unhydrolysable Analogs of Cyclic Adenosine- 3', 5' - Monophosphate Demonstrating Growth Inhibition and Differentiation in Human Cancer Cells"
15 Genieser, H.-G.; Winkler, E.; Butt, E.; Zorn, M.; Schulz, S.; Iwitzki, F.; Störmann, R.; Jastorff, B.; Doeskeland, S.O.; Oegreid, D.; Ruchaud, S.; Lanotte, M., Carbohydr. Res., 234, 217 - 235 (1992): "Derivates of 1-ß-D-Ribofuranosylbenzimidazole 3', 5'-phosphate that Mimic the Actions of Adenosine 3', 5',- phosphate (cAMP) and Guanosine 3', 5'- phosphate (cGMP)"
14 Iwitzki, F.; van Bemmelen, M.X.P.; Genieser, H.-G.; Jastorff, B., Proc. Intl. Conf. Second Messengers Phosphoprot. UK (1992): "New Affinity Materials for Cyclic AMP Binding Proteins"
13 Iwitzki, F.; van Bemmelen, M.X.P.; Genieser, H.-G.; Jastorff, B., 3rd Swed.- Germ. Workshop Nucleic Acid Synth. Struct. Funct. Sweden (1992): "cAMP Analogues Designed for Affinity Chromatography"
12 Schultz, S.; Iwitzki, F.; Genieser, H.-G.; van Bemmelen, M.X.P.; Jastorff, B., 8th International Conference on Second Messengers & Phosphoproteins (1992): "cAMP Analogues Designed for Affinity Chromatography and CA Kinase Characterization"
11 Genieser, H.-G.; Winkler, E.; Butt, E.; Zorn, M.; Schulz, S.; Iwitzki, F.; Störmann, R.; Jastorff, B.; Doskeland, S.O.; Ogreid, D.; Ruchaud, S.; Lanotte, M., Carbohydr. Res. , 234, 217 - 235 (1992): "Derivatives of 1-Beta-D-Ribofuranosylbenzimidazole 3',5'-Phosphate that Mimic the Actions of Adenosine 3',5'-Phosphate (cAMP) and Guanosine 3',5'-Phosphate (cGMP)."
10 Van Ments-Cohen, M.; Genieser, H.-G.; Jastorff, B.; Van Haastert, P.J.M.; Schaap, P., FEMS Microbiol. Lett., 82, 9 - 14 (1991): "Kinetics and Nucleotide Specificity of a Surface cAMP Binding Site in Dictyostelium discoideum, which is not Down-regulated by cAMP"
9 Sandberg, M.; Butt, E.; Nolte, C.; Fischer, L.; Halbrügge, M.; Beltmann, J.; Jahnsen, T.; Genieser, H.-G.; Jastorff, B.; Walter, U., Biochem. J., 279, 521 - 527 (1991): "Characterization of Sp- 5, 6- dichloro-1-ß-D-ribofuranosylbenzimidazole- 3',5'- monophosphorothioate (Sp-5,6-DCl-cBIMPS) as a Potent and Specific Activator of cyclic AMP- dependent Protein Kinase in Cell Extracts and Intact Cells"
8 Van Lookeren Campagne, M.M.; Diaz, F.V.; Jastorff, B.; Winkler, E.; Genieser, H.-G.; Kessin, R.W., J. Biol. Chem., 265, 5847 - 5854 (1990): "Characterization of the Yeast Low Km cAMP- Phosphodiesterase With cAMP Analogues"
7 Dostmann, W.R.G.; Taylor, S.S.; Genieser, H.-G.; Jastorff, B.; Doeskeland, S.O.; Oegreid, D., J. Biol. Chem., 265, 10484 - 10491 (1990): "Probing the Cyclic Nucleotide Binding Sites of cAMP-Dependent Protein Kinase I and II with Analogs of Adenosine- 3', 5'- Cyclic Phosphorothioates"
6 Jastorff, B.; Butt, E.; Schultz, C.; Metschies, T.; Winkler, E.; Dostmann, W.; Walter, U.; van Bemmelen, M.; Genieser, H.-G., 7th International Conference on Second Messenger & Phosphoproteins Japan (1990): "A Rational Approach to Design Antagonists of Cyclic AMP, Cyclic GMP and 1, 4, 5 - IP3"
5 Meijer, L.; Dostmann, W.; Genieser, H.-G.; Butt, E.; Jastorff, B., Develop. Biol., 133, 58 - 66 (1989): "Starfish Oocyte Maturation: Evidence for a Cyclic AMP-Dependent Inhibitory Pathway"
4 Jastorff, B.; Genieser, H.-G.; Dostmann, W.; Bottin-Weber, U., Patent WO8907108 of August 10 (1989): "Process for Producing Nucleoside-3', 5'-Cyclophosphates and Nucleoside-3', 5'- Cyclothiophosphates"
3 Genieser, H.-G.; Butt, E.; Bottin, U.; Jastorff, B., J. Syn. Org. Chem., 1 (1989): "Synthesis of the 3', 5'-Cyclic Phosphates from Unprotected Nucleosides"
2 Dostmann, W.; Braumann, T.; Bottin, U.; Genieser, H.-G.; Stohrer, W.-D.; Jastorff, B., Universität Bremen (1989): "Mechanism of cAMP/Protein Kinase Type II Interactions: Studies with New cAMP Agonists and Antagonists"
1 Genieser, H.-G.; Dostmann, W.; Bottin, U.; Butt, E.; Jastorff, B., Tetrahedron Lett., 29, 2803 - 2804 (1988): "Synthesis of Nucleoside-3', 5'-cyclic Phosphorotioates by Cyclothiophosphorylation of Unprotected Nucleosides"