0 Items - $0.00
Categories
A to Z

t⁶-Ado

N⁶- Carbamoylthreonyladenosine ( t⁶-Ado )
Cat. No.: C 022
    
CAS No.: [24719-82-2]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 022-10
Unit: 10 µmol / ~4.3 mg
$178.00
Nucleoside with anticodon-adjacent base present in transfer ribonucleic acid. Detailed technical information available. References: Schweizer et al., Biochem. Biophys. Res. Commun., 40, 1046 - 1052 (1970); Hagemeier et al., J. Clin. Chem. Clin. Biochem., 22, 175 - 184 (1984); Morin et al, RNA, 4, 24 - 37(1998).
Cat. No. C 022
CAS number [24719-82-2]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₅H₁₉N₆O₈ · Na
Molecular weight [g/mol] 434,4
Absorption max [nm] 270
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 24900
  • 1. Bullinger D., Neubauer H., Fehm T., Laufer S., Gleiter C. H.Kammerer B., BMC Biochemistry, 8, 1 - 14 (2007), "Metabolic Signature of Breast Cancer Cell Line MCF-7: Profiling of Modified Nucleosides via LC-IT MS Coupling"
  • 2. Morin A., Auxilien S., Senger B., Tewari R.Grosjean H., RNA, 4, 24 - 37 (1998), "Structural Requirements for Enzymatic Formation of Threonylcarbamoyladenosine (t6A) in tRNA: An in Vivo Study with Xenopus laevis oocytes"
  • 3. Hong C. I., Chheda G. B., Murphy G. P.Mittelmann A., Biochem. Pharmacol., 22, 1927 - 1932 (1997), "Metabolism of N-(purin-6-ylcarbamoyl)-L-threonine Riboside in Rat and Man"
  • 4. Topp H., Groß H., Heller-Schöch G.Schöch G., Nucleosides Nucleotides, 12, 585 - 596 (1993), "Determination of N6-Threoninocarbonyladenosine, N2, N2-Dimethylguanosine, Pseudouridine and Other Ribonucleosides in Human Breast Milk"
  • 5. Hagemeier E., Kemper K., Boos K. S.Schlimme E., J. Clin. Chem. Clin. Biochem., 22, 175 - 184 (1984), "Development of a Chromatographic Method for the Quantitative Determination of Minor Ribonucleosides in Physiological Fluids. Characterization and Quantitative Determination of Minor Ribonucleosides in Physiological Fluids, Part I"
  • 6. Weissenbach J.Grosjean H., Eur. J. Biochem., 116, 207 - 213 (1981), "Effect of Threonylcarbomoyl modification(t6A) in Yeast tRNA Arg. III on Codon-anticodon and Anticodon-anticodon Interactions. A Thermodynamic and Kinetic Evaluation"
  • 7. Miller J. P., Hussain Z.Schweizer M. P., Nucleic Acids Res., 3, 1185 - 1201 (1976), "The Involvement of the Anticodon Adjacent Modified Nucleoside N-(9-(beta-D-ribofuranosyl)Purine-6-ylcarbamoyl)-threonine in the Biological Function of E. Coli"
  • 8. Dutta S. P., Hong C. I., Murphy G. P., Mittelman A.Chheda G. B., Bio.Chem., 14, 3144 - 3151 (1975), "Synthesis and Properties of the Naturally Occuring N-[(9-beta-D-Ribofuranosylpurin-6-yl)-N-methylcarbamoyl]-L-threonine (mt6A) and Other Related Synthetic Analogs"
  • 9. Parthasarathy R., Ohrt J. M.Chheda G. B., J. Am. Chem. Soc., 96, 8087 - 8094 (1974), "Structure and Stereochemistry of Nucleic Acid Components and Their Reaction Products. III. Crystal structure of the Potassium Salt of N-(Purin-6-ylcarbamoyl)-L-threonine. Possible Role of Hypermodified Bases Adjacent to Anticodon in Codon-anticodon Intera"
  • 10. Elkins B. N.Keller E. B., Biochemistry, 22, 4622 - 4628 (1974), "The Enzymatic Synthesis of N-(purin-6-ylcarbamoyl)threonine, an Anticodon-adjacent Base in Transfer Ribonucleic Acid"
  • 11. Parthasarathy R., Ohrt J. M.Chheda G. B., Biochem. Biophys. Re. Commun., 60, 211 - 218 (1974), "Conformation and Possible Role of Hypermodified Nucleosides Adjacent to 3'-end of Anticodon in tRNA: N-(purin-6-ylcarbamoyl)-L-Threonine Riboside"
  • 12. Korner A.Soll D., FEBS Lett., 39, 301 - 306 (1974), "N-(Purin-6-ylcarbamoyl)threonine: Biosynthesis in Vitro in Transfer RNA by an Enzyme Purified from Escheria Coli"
  • 13. Powers D. M.Peterkofsky A., J. Biol. Chem., 247, 6394 - 6401 (1972), "The Presence of N-(purin-6-ylcarbamoyl)threonine in Transfer Ribonucleic Acid Species whose Codons Begin with Adenine"
  • 14. Chheda G. B., Hong C. I., Piskorz C. F.Harmon G. A., Biochem. J., 127, 515 - 519 (1972), "Biosynthesis of N-(purin-6-ylcarbamoyl)-L-threonine Riboside. Incorporation of L-threonine in Vivo into Modified Nucleoside of Transfer Ribonucleic Acid"
  • 15. Dyson W. H., Hall R. H., Hong C. I., Dutta S. P.Chheda G. B., Can. J. Biochem., 50, 237 - 243 (1972), "Cytokinin Activity of a Group of Ureidopurine Derivatives Related to the tRNA Component, N-(purin-6-ylcarbamoyl)threonine"
  • 16. Schweizer M. P., McGrath K.Baczynskvj L., Biochem. Biophys. Res. Commun., 40, 1046 - 1052 (1970), "The Isolation and Characterization of N-[9-(beta-D-ribofuranosyl)-purin-6-ylcarbamoyl] Glycine from Yeast Transfer RNA"
  • 17. Schweizer M. P., Chheda G. B., Baczynskvj L.Hall R. H., Biochemistry, 8, 3283 - 3289 (1969), "Aminoacyl Nucleosides. VII. N-(Purin-6-ylcarbamoyl)threonine. A New Component of Transfer Ribonucleic Acid."