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Sp-c-diGMPS

Cyclic diguanosine monophosphorothioate, Sp- isomer ( Sp-c-diGMPS ), sodium salt
Monophosphorothioate analogue of c-diGMP
Cat. No.: C 125
    
CAS No.: [1259875-39-2]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 125-001
Unit: 0.1 µmol / ~71 µg
$286.00
For other salt forms please inquire. Sulfur-modified analogue of the bacterial second messenger c-diGMP (Cat. No. C 057) which can be useful in studies on ligand-receptor interactions. Rp-c-diGMPS is also offered (Cat. No. C 124). Detailed technical information available. References: Chen et al., Vaccine, 28, 3080 - 3085 (2010); Shanahan et al., J. Am. Chem. Soc., 133, 15578 - 15592 (2011).
Cat. No. C 125
CAS number [1259875-39-2]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₄N₁₀O₁₃P₂S (free acid)
Molecular weight [g/mol] 706,5 (free acid)
Absorption max [nm] 253
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 23700
  • 1. Shanahan C. A., Gaffney B. L., Jones R. A.Strobel S. A., Biochemistry, 52, 365 - 377 (2013), "Identification of c-di-GMP Derivatives Resistant to an EAL Domain Phosphodiesterase"
  • 2. Shanahan C. A., Gaffney B. L., Jones R. A.Strobel S. A., J. Am. Chem. Soc., 133, 15578 - 15592 (2011), "Differential Analogue Binding by Two Classes of C-Di-GMP Riboswitches"
  • 3. Yan H., Wang X., KuoLee R.Chen W., Bioorg. Med. Chem. Lett., 18, 5631 - 5634 (2008), "Synthesis and Immunostimulatory Properties of the Phosphorothioate Analogues of c-di-GMP"
  • 4. Ross P., Mayer R., Weinhouse H., Amikam D., Huggirat Y., Benziman M., de Vroom E., Fidder A., de Paus P., Sliedregt L. A. J. M., van der Marel G. A.van Boom J. H., J. Biol. Chem., 265, 18933 - 18943 (1990), "The Cyclic Diguanylic Acid Regulatory System of Cellulose Synthesis in Acetobacter xylinum. Chemical Synthesis and Biological Activity of a Nucleotide Dimer, Trimer, and Phosphothioate Derivatives"