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Alternative structural projections:

Sp-8-PIP-cAMPS

8- Piperidinoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-PIP-cAMPS ), sodium salt
Site selective analogue of the PDE-resistant PKA agonist Sp-cAMPS
Cat. No.: P 005
    
CAS No.: [156816-35-2]
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Product Name Price (net) Qty
Cat. No.: P 005-05
Unit: 5 µmol / ~2.3 mg
$149.00
For other salt forms please inquire. Lipophilic site-selective cyclic AMP analogue with extremely high selectivity for site B of protein kinase A type II. Acts synergistically with site A activating analogues for selective activation of type II. Metabolically stable and good membrane permeability. Detailed technical information and updated reference list available. Reference: Øgreid et al., Eur. J. Biochem., 221, 1089 - 1094 (1994).
Cat. No. P 005
CAS number [156816-35-2]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₅H₂₀N₆O₅PS · Na
Molecular weight [g/mol] 450,4
Modifications 8-cAMP
Target PKA (cAK) Activator
Lipophilicity 2.39
Absorption max [nm] 273
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15000
  • 1. Pfeifer A., Ruth P., Dostmann W., Sausbier M., Klatt P.Hofmann F., in Rev. Physiol. Biochem. Pharmacol. Berlin / Springer, 135, 105 - 149 (1999), "Structure and Function of cGMP-Dependent Protein Kinases"
  • 2. Tasken K., Aandahl E. M., Aukrust P., Müller F., Froland S. S.Hansson V., Intl. Patent Appl. PCT, 0, 0 - 0 (1998), "Use of Immunomodulating Agents"
  • 3. Oegreid D., Dostmann W., Genieser H.-G., Niemann P., Doeskeland S. O.Jastorff B., Eur. J. Biochem., 221, 1089 - 1094 (1994), "(Rp)- and (Sp)- 8- Piperidinoadenosine- 3', 5'- (cyclic) Thiophosphates Discriminate Completely Between Site A and B of the Regulatory Subunits of cAMP-dependent Protein Kinase Type I and II"
  • 4. Bologa C., Muresan S., Liauw S., Iwitzki F.Chiriac A., Anal. Univ. Timisoara, 2, 27 - 36 (1993), "Quantitative Structure-Activity Study by the MTD-Method for cAMP-Derivatives with Large Substituents in Positions 2 and 8"
  • 5. Jastorff B., Proceeding of the 8th. Internatl. Conference on Second Messengers & Phosphoproteins UK, 0, 0 - 0 (1992), "A New Generation of Cyclic Nucleotide Analogues : Site Specific, Enzyme Selective, Agonistic or Antagonistic and Resistant to Hydrolysis"