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Sp-8-pCPT-PET-cGMPS

8- (4- Chlorophenylthio)- ß- phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-pCPT-PET-cGMPS ), sodium salt
Highly membrane-permeant, PDE-resistant PKG agonist
Cat. No.: C 047
    
CAS No.: [1262749-63-2]
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Product Name Price (net) Qty
Cat. No.: C 047-01
Unit: 1 µmol / ~0.6 mg
$143.00
For other salt forms please inquire. Membrane-permeant activator of cyclic GMP-dependent protein kinase, but most probably inhibitor of the retinal type cGMP-gated ion channel, thus suitable for distinction between kinase and ion channel mediated effects. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. More lipophilic and membrane-permeant compared to Sp-8-Br-PET-cGMPS (Cat. No. P 008). Detailed technical information available. Reference: Jäger et al., Br. J. Pharmacol., 161, 1645 - 1660 (2010).
Cat. No. C 047
Patent Information Protected under patents US 5,625,056 and DE 42 17679 issued to BIOLOG LSI
CAS number [1262749-63-2]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₂₄H₁₈ClN₅O₆PS₂ · Na
Molecular weight [g/mol] 626
Modifications 1-cGMP, 2-cGMP, 8-cGMP
Target PKG (cGK) Activator
Lipophilicity 3.64
Absorption max [nm] 276
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 40000
  • 1. Jäger R., Russwurm C., Schwede F., Genieser H.-G., Koesling D.Russwurm M., J. Biol. Chem., 287, 1210 - 1219 (2012), "Activation of PDE10 and PDE11 Phosphodiesterases"
  • 2. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"