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Sp-8-OH-cAMPS

8- Hydroxyadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-OH-cAMPS ), sodium salt
Polar analogue of the PDE-resistant PKA agonist Sp-cAMPS
Cat. No.: H 005
    
CAS No.: [749843-87-6]
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Product Name Price (net) Qty
Cat. No.: H 005-05
Unit: 5 µmol / ~1.9 mg
$198.00
For other salt forms please inquire. Polar, membrane-impermeant analogue of the protein kinase A activator Sp-cAMPS (Cat. No. A 003), e.g. for the study of extracellular cAMP receptors. If applied by patch clamp techniques, Sp-8-OH-cAMPS should remain trapped inside the cell. Highly resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Detailed technical information available. Reference: Otmakhov & Lisman, J. Neurophysiol., 87, 3018 - 3032 (2002).
Cat. No. H 005
CAS number [749843-87-6]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₁N₅O₆PS · Na
Molecular weight [g/mol] 383,3
Modifications 8-cAMP
Target PKA (cAK) Activator
Lipophilicity 1.13
Absorption max [nm] 268
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 11000