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Alternative structural projections:

Sp-8-Br-PET-cGMPS

8- Bromo- β- phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-Br-PET-cGMPS ), sodium salt
Membrane-permeant and PDE-resistant PKG agonist
Cat. No.: P 008
    
CAS No.: [172806-21-2]
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Product Name Price (net) Qty
Cat. No.: P 008-05
Unit: 5 µmol / ~2.8 mg
$143.00
For other salt forms please inquire. Membrane-permeant inhibitor of the retinal type cGMP-gated ion channel (cGMP antagonist) but activator of cyclic GMP-dependent protein kinase I α and I ß (cGMP agonist). Suitable for distinction between kinase and ion channel mediated effects. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. More lipophilic and membrane-permeant compared to Sp-8-pCPT-cGMPS (Cat. No. C 014). Detailed technical information and updated reference list available on request. Reference: Butt et. al., Br. J. Pharmacol., 116, 3110 - 3116 (1995).
Cat. No. P 008
Patent Information Protected under patents US 5,625,056 and DE 42 17679 issued exclusively to BIOLOG LSI
CAS number [172806-21-2]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₈H₁₄BrN₅O₆PS · Na
Molecular weight [g/mol] 562,3
Modifications 1-cGMP, 2-cGMP, 8-cGMP
Target PKG (cGK) Activator
Lipophilicity 3.03
Absorption max [nm] 256
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 40000
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