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Alternative structural projections:


8- Bromo- β- phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-Br-PET-cGMPS ), sodium salt
Membrane-permeant and PDE-resistant PKG agonist
Cat. No.: P 008
CAS No.: [172806-21-2]
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Product Name Price (net) Qty
Cat. No.: P 008-05
Unit: 5 µmol / ~2.8 mg
For other salt forms please inquire. Membrane-permeant inhibitor of the retinal type cGMP-gated ion channel (cGMP antagonist) but activator of cyclic GMP-dependent protein kinase I α and I ß (cGMP agonist). Suitable for distinction between kinase and ion channel mediated effects. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. More lipophilic and membrane-permeant compared to Sp-8-pCPT-cGMPS (Cat. No. C 014). Detailed technical information and updated reference list available on request. Reference: Butt et. al., Br. J. Pharmacol., 116, 3110 - 3116 (1995).
Cat. No. P 008
Patent Information Protected under patents US 5,625,056 and DE 42 17679 issued exclusively to BIOLOG LSI
CAS number [172806-21-2]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₈H₁₄BrN₅O₆PS · Na
Molecular weight [g/mol] 562,3
Modifications 1-cGMP, 2-cGMP, 8-cGMP
Target PKG (cGK) Activator
Lipophilicity 3.03
Absorption max [nm] 256
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 40000
  • 1. Sergeant G. P., Johnston L., McHale N. G., Thornbury K. D.Hollywood M. A., J. Physiol.-London, 574, 167 - 181 (2006), "Activation of the cGMP/PKG Pathway Inhibits Electrical Activity in Rabbit Urethral Interstitial Cells of Cajal by Reducing the Spatial Spread of Ca2+ Waves"
  • 2. Cuong D. V., Kim N., Youm J. B., Joo H., Warda M., Lee J. W., Park W. S., Kim T., Kang S., Kim H.Han J., Amer. J. Physiol.-Heart Circ. Phy., 290, 1808 - 1817 (2006), "Nitric Oxide-cGMP-Protein Kinase G Signaling Pathway Induces Anoxic Preconditioning Through Activation of ATP-Sensitive K+ Channels in Rat Hearts"
  • 3. Brown R. L., Strassmaier T., Brady J. D.Karpen J. W., Curr. Pharmaceut. Design, 12, 3597 - 3613 (2006), "The Pharmacology of Cyclic Nucleotide-Gated Channels: Emerging from the Darkness"
  • 4. Lohmann S. M.Walter U., Frontiers Biosci., 10, 1313 - 1328 (2005), "Tracking Functions of cGMP-dependent Protein Kinase"
  • 5. Snellman J.Nawy S., J. Neurosci., 24, 6621 - 6628 (2004), "cGMP-dependent Kinase Regulates Response Sensivity of the Mouse on Bipolar Cell"
  • 6. Barnstable C. J., Wei J. Y.Han M. H., Neurochem. Int., 45, 875 - 884 (2004), "Modulation of Synaptic Function by cGMP and cGMP-gated Cation Channels"
  • 7. Christensen A. E.Doeskeland S. O., Handbook of Cell Signaling Academic Press/Elsevier Science San Diego CA, 2, 549 - 554 (2003), "Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling"
  • 8. Yan L., Zhang Q. H., Scholz P. M.Weiss H. R., Clin. Exp. Pharmacol. Physiol., 30, 943 - 950 (2003), "Cyclic GMP Protein Kinase Activity Is Reduced in Thyroxine-induced Hypertrophic Cardiac Myocytes"
  • 9. Wei J.-Y., Jin X. T., Cohen E. D., Daw N. W.Barnstable C. J., Brain Res., 927, 42 - 54 (2002), "cGMP-induced Presynaptic Depression and Postsynaptic Facilitation at Glutamatergic Synapses in Visual Cortex"
  • 10. Rimon G.Rubin M., BBA - Gen. Subj., 1570, 113 - 120 (2002), "Channel Modulators Affect PGE(2) Binding to Bovine Aortic Endothelial Cells"
  • 11. Rho E. H., Perkins W. J., Lorenz R. R., Warner D. O.Jones K. A., J. Appl. Physiol., 92, 257 - 263 (2002), "Differential Effects of Soluble and Particulate Guanylyl Cyclase on Ca2+ Sensitivity in Airway Smooth Muscle"
  • 12. Jang E. K., Azzam J. E., Dickinson N. T., Davidson M. M. L.Haslam R. J., Brit. J. Haematol., 117, 664 - 675 (2002), "Roles for Both Cyclic GMP and Cyclic AMP in the Inhibition of Collagen-induced Platelet Aggregation by Nitroprusside"
  • 13. Deng W.Baker D. A., Mol. Microbiol., 44, 1141 - 1151 (2002), "A Novel Cyclic GMP-dependent Protein Kinase is Expressed in the Ring Stage of the Plasmodium Falciparum Life Cycle"
  • 14. Spicuzza L., Belvisi M. G., Birrell M. A., Barnes P. J., Hele D. J.Giembycz M. A., Br. J. Pharmacol., 133, 1201 - 1212 (2001), "Evidence that the Anti-Spasmogenic Effect of the Beta-Adrenoceptor Agonist, Isoprenaline, on Guinea-Pig Trachealis is not Mediated by Cyclic AMP-dependent Protein Kinase"
  • 15. Staples K. J., Bergmann M., Tomita K., Houslay M. D., McPhee I., Barnes P. J., Giembycz M. A.Newton R., J. Immunol., 167, 2074 - 2080 (2001), "Adenosine 3', 5'-cyclic Monophosphate (cAMP)-dependent Inhibition of IL-5 from Human T Lymphocytes is not Mediated by the cAMP-dependent Protein Kinase A(1)"
  • 16. Yan L., Patel K. N., Zhang Q. H., Scholz P. M.Weiss H. R., Eur. J. Pharmacol., 426, 11 - 19 (2001), "Interaction between Cyclic GMP Protein Kinase and Cyclic AMP May be Diminished in Stunned Cardiac Myocytes"
  • 17. Han J., Kim N., Kim E., Ho W.-K.Earm Y. E., J. Biol. Chem., 276, 22140 - 22147 (2001), "Modulation of ATP-sensitive Potassium Channels by cGMP-dependent Protein Kinase in Rabbit Ventricular Myocytes"
  • 18. Ferrero R., Rodriguez-Pascual F., Miras-Portugal M. T.Torres M., J. Neurochem., 75, 2029 - 2039 (2000), "Nitric Oxide-Sensitive Guanylyl Cyclase Activity Inhibition through Cyclic GMP-Dependent Dephosphorylation"
  • 19. Wei J.-Y., Cohen E. D., Genieser H.-G.Barnstable C. J., J. Mol. Neurosci., 10, 53 - 64 (1998), "Substituted cGMP Analogs Can Act as Selective Agonists of the Rod Photoreceptor cGMP-Gated Cation Channel"
  • 20. Wei J.-Y., Roy D. S., Leconte L.Barnstable C. J., Prog. Neurobiol., 56, 37 - 64 (1998), "Molecular and Pharmacological Analysis of Cyclic Nucleotide-Gated Channel Function in the Central Nervous System"
  • 21. Wei J.-Y., Cohen E. D.Barnstable C. J., Neurosci. Lett., 233, 37 - 40 (1997), "Direct Blockade of Both Cloned Rat Rod Photoreceptor Cyclic nucleotide-gated Non-selective Cation (CNG) Channel @-subunit and Native CNG Channels from Xenopus Rod Outer Segments by H-8, a Non-specific Cyclic Nucleotide-dependent Protein Kinase Inhibitor"
  • 22. Wei J. Y., Cohen E. D., Yan Y.-Y., Genieser H.-G.Barnstable C. J., Biochemistry, 35, 16815 - 16823 (1996), "Identification of Competitive Antagonists of the Rod Photoreceptor cGMP-Gated Cation Channel: Beta-Phenyl-1,N(2)-Etheno-Substituted cGMP Analogues as Probes of the cGMP-Binding Site"
  • 23. Wei J. Y., Cohen E. D., Yan Y.-Y., Genieser H.-G.Barnstable C. J., American Society for Neuroscience, 0, 880 - 0 (1996), "PET-substituted cGMP Analogs: Novel Antagonists of Rod Photoreceptor cGMP-gated Channel"
  • 24. Butt E., Pöhler D., Genieser H.-G., Huggins J. P.Bucher B., Br. J. Pharmacol., 116, 3110 - 3116 (1995), "Inhibition of Cyclic GMP-dependent Protein Kinase-mediated Effects by (Rp)-8-bromo-PET- cyclic GMPS"
  • 25. Genieser H.-G., Proc. 9. Int. Conf. Second Mess. & Phosphoprot. TN USA, 0, 0 - 0 (1995), "Lipophilic Ranking of Biologically Important Cyclic Nucleotides"
  • 26. Genieser H.-G., Bucher B.Butt E., 9th International Conference on Second Messenger & Phosphoproteins, 0, 0 - 0 (1995), "Rp-8-Br-PET-cGMPS, A New Potent Inhibitor of Cyclic GMP-dependent Protein Kinase"

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