Membrane-permeant precursor of the PDE-resistant protein kinase A activator Sp-8-Br-cAMPS (Cat. No. B 002
). Metabolic bioactivation by esterases releases the active analogue, which is trapped inside the cell. Chemical hydrolysis can produce some 8-Br-cAMP as well. Detailed technical information available. Compare: Maronde et al., J. Pineal Res
, 183 - 185 (2001). Biolog also offers Phosphate tris(acetoxymethyl)ester
, Cat. No. P 030
) which is recommended as control reagent in nucleotide-AM ester applications.