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Alternative structural projections:

Sp-8-Br-cAMPS

8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-Br-cAMPS ), sodium salt
Membrane-permeant and PDE-resistant PKA agonist
Cat. No.: B 002
    
CAS No.: [127634-20-2]
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Product Name Price (net) Qty
Cat. No.: B 002-05
Unit: 5 µmol / ~2.2 mg
$104.00
For other salt forms please inquire. Metabolically resistant activator of protein kinase A (cyclic AMP agonist). No metabolic side effects as observed with dibutyryl-cAMP or 8-Br-cAMP. Significantly more lipophilic and membrane-permeant compared to Sp-cAMPS (Cat. No. A 003). Detailed technical information and updated reference list available on request. References: Schaap et al., J. Biol. Chem., 268, 6323 - 6331 (1993); Sandnes et al., Pharmacol. Toxicol., 79, 15 - 22 (1996).
Cat. No. B 002
CAS number [127634-20-2]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₀BrN₅O₅PS · Na
Molecular weight [g/mol] 446,2
cAMP modified at the exocyclic oxygen axial (Sp-)
Modifications 8-cAMP
Target PKA (cAK) Activator
Lipophilicity 1.66
Absorption max [nm] 264
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000