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Sp-8-AHA-cAMPS

8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-AHA-cAMPS )
PDE-resistant Sp-cAMPS functionalized for immobilization or conjugation with markers and dyes
Cat. No.: A 071
    
CAS No.: [214272-03-4]
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Product Name Price (net) Qty
Cat. No.: A 071-05
Unit: 5 µmol / ~2.3 mg
$143.00
PDE-stable cyclic AMP analogue suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases) or for coupling of various labelling structures including fluorophores. PDE-resistant form of 8-AHA-cAMP, Cat. No. A 011. Detailed technical information available. Reference: Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006); Bertinetti et al., BMC Chem. Biol., 9: 3 (2009).
Cat. No. A 071
CAS number [214272-03-4]
Purity > 98% HPLC
Salt form Free acid
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₂₆N₇O₅PS
Molecular weight [g/mol] 459,5
cAMP modified at the exocyclic oxygen axial (Sp-)
Modifications 8-cAMP
Target PKA (cAK) Activator
Lipophilicity 1.67
Absorption max [nm] 273
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Hanke S. E., Bertinetti D., Badel A., Schweinsberg S., Genieser H.-G.Herberg F. W., N. Biotechnol., 28, 294 - 301 (2011), "Cyclic Nucleotides as Affinity Tools: Phosphorothioate cAMP Analogues Adress Specific PKA Subproteomes"
  • 2. Bertinetti D., Schweinsberg S., Hanke S. E., Schwede F., Bertinetti O., Drewianka S., Genieser H.-G.Herberg F. W., BMC Chem Biol, 9, 0 - 0 (2009), "Chemical tools selectively target components of the PKA system"
  • 3. Schweinsberg S., Moll D., Burghardt N. C., Hahnefeld C., Schwede F., Zimmermann B., Drewianka S., Werner L., Kleinjung F., Genieser H.-G., Schuchhardt J.Herberg F. W., Proteomics, 8, 1212 - 1220 (2008), "Systematic interpretation of cyclic nucleotide binding studies using KinetXBase"
  • 4. Moll D., Prinz A., Gesellchen F., Drewianka S., Zimmermann B.Herberg F. W., J. Neural. Transm., 113, 1015 - 1032 (2006), "Biomolecular Interaction Analysis in Functional Proteomics"