Alternative structural projections:
Phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and other markers. Detailed technical information available. This ligand is also available with a longer spacer (Sp-8-AHA-cAMPS; Cat. No. A 071). Reference: Bertinetti et al., BMC Chem. Biol., 9: 3 (2009)
| Cat. No. | A 094 |
| CAS number | [221904-84-3] |
| Purity | > 98% HPLC |
| Salt form | Free acid |
| Appearance | Solid |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₂H₁₈N₇O₅PS |
| Molecular weight [g/mol] | 403.4 |
| cAMP modified at the exocyclic oxygen | axial (Sp-) |
| Modifications | 8-cAMP |
| Target | PKA (cAK) Activator |
| Lipophilicity | 0.88 |
| Absorption max [nm] | 273 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 17000 |
| UV pH value | 7 |
| Solvent for UV data | Water |
- 1. Chepurny O. G., Bertinetti D., Diskar M., Leech C. A., Afshari P., Tsalkova T., Cheng X., Schwede F., Genieser H.-G., Herberg F. W.Holz G. G., Mol. Endocrinol., 27, 1267 - 1282 (2013), "Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag"
- 2. Hanke S. E., Bertinetti D., Badel A., Schweinsberg S., Genieser H.-G.Herberg F. W., N. Biotechnol., 28, 294 - 301 (2011), "Cyclic Nucleotides as Affinity Tools: Phosphorothioate cAMP Analogues Adress Specific PKA Subproteomes"
- 3. Bertinetti D., Schweinsberg S., Hanke S. E., Schwede F., Bertinetti O., Drewianka S., Genieser H.-G.Herberg F. W., BMC Chem Biol, 9, 0 - 0 (2009), "Chemical tools selectively target components of the PKA system"
